Recombinant DNA clone containing a genomic fragment of PfHRP-II

Details Recombinant DNA clone containing a genomic fragment of PfHRP-II Recombinant DNA clone containing a genomic fragment of PfHRP-II

1991-11-14

1994-03-22

Lacey, David L.

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

436536, 5303882, 5303884, 5303895, G01N 33536, A61K 3516, C07K 1528

Patent

active

052963829

ABSTRACT:
The present invention resides, in part, in cloned DNA fragments encoding a histidine-rich protein of Plasmodium falciparum (PfHRP-II). PfHRP-II is a malarial antigen that is secreted by the parasite into erythrocytes. The protein is characterized by tandem repeats of high histidine, alanine and aspartate content. The protein is found to have high affinity for divalent cations. Cloning and characterization of the PfHRP-II gene are described, as are antibodies against PfHRP-II.

REFERENCES:
patent: 4196265 (1980-04-01), Kopnowski et al.
patent: 5001225 (1991-03-01), Taylor
patent: 5130416 (1992-07-01), Wellems et al.
Leech et al., J. Cell Biol 98:1256-1264 1984.
Wellems, et al., Molecular Strategies of Parasitic Invasion pp. 47-58 1987.
Valler, Diagnostic Horizons 2(1):1-6 '78.
Wellems et al. Proc. Natl. Acad. Sci, USA vol. 83, pp. 6065-6069, (1986).

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