Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1990-05-03
1992-07-14
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530395, C07K 1300, C07K 1504, A61K 39015
Patent
active
051304163
ABSTRACT:
A histidine rich antigen, designated PfHRP-II, has been synthesized from a recombinant DNA clone containing a genomic fragment of Plasmodium falciparum. PfHRP-II is a protein exported from the parasite into the body fluid. This protein passes through the host erythrocyte in concentrated packets and is released from the infected erythrocyte into the body fluid. The antigen has been isolated and is useful for protection against malaria.
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Wellems, T. E. and Howard, R. J. Aug. 1986, PNAS 83:6065-6069, Homologous genes encode two distinct histidine-rich proteins.
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Merrified, B. Science, vol. 232, pp. 341-347, "Solid Phase Synthesis," 1985, See last page.
Wellems, T. E. in Molecular Strategies of Parasitic Invasion, 1987, pp. 47-58.
Brown, 1984, Nature, "Blood-Stage antigens Cloned".
Godson, et al., 1983, Nature, "Identification and Chemical Synthesis of a Tandemly Repeated Immunogenic Region of Plasmodium knowlesi Circumsporozoite Protein" 305:29-32.
Bellou, et al, 1985, Science, "Immunigencity of Synthetic Peptide from Circumsporozoite Protein of Plasmodium faciparum" 228:996-999.
Dame, et al., 1984, Science, "Structure of the Gene Encoding the Immunodominant Surface Antigen on the Sporozoite of the Human Malaria Parasite Plasmodium falciparum" 225:593-599.
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Howard Russell J.
Wellems Thomas E.
Benson Robert
Cunningham T.
Moskowitz Margaret
The United States of America as represented by the Department of
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