Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1993-06-14
1998-05-05
Eisenschenk, Frank C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303919, 5303871, 530395, 530350, 530867, 530866, 5303917, 5303913, 5303873, 4241331, 4241831, C07K 1900, C07K 1646, C07K 14725
Patent
active
057476543
ABSTRACT:
The present invention relates to disulfide-stabilized recombinant polypeptide molecules which have the binding ability and specificity for another peptide, such as the variable region of an antibody molecule. Methods of producing these molecules and nucleic acid sequences encoding these molecules are also described. In particular, the invention discloses Fv antibody fragments stabilized by a disulfide bond connecting the V.sub.H and V.sub.L regions of the Fv fragment. The .alpha. and .beta. chains of T cell receptors may be similarly stabilized by means described in the invention.
REFERENCES:
patent: 4946778 (1990-08-01), Ladner et al.
patent: 5091513 (1992-02-01), Huston et al.
patent: 5132405 (1992-07-01), Huston et al.
Batra et al., Proc. Natl. Acad. Sci. USA, 89:5967-5871 (1992).
Bird et al., Science, 242:423-426 (1988).
Brinkmann et al., J. Immunology, 150:2774-2782 (1993).
Buchner et al., Anal. Biochem., 205:263-270 (1992).
Glockshuber et al., Biochemistry, 29:1362-1367 (1990).
Pantoliano et al., Biochemistry, 30:10117-10125 (1991).
Stemmer et al., Biotechniques, 14(2):256-265 (1993).
Brinkmann et al. J. Immunology 150:2774-2782 (Apr. 1, 1993). 1994)!.
Huston et al., Proc. Natl. Acad. Sci. USA, 85:5879-5883 (1988).
Pack et al., Biochemistry 31:1579 (1992).
Brinkmann Ulrich
Jung Sun-Hee
Lee Byungkook
Pastan Ira H.
Eisenschenk Frank C.
The United States of America as represented by the Department of
LandOfFree
Recombinant disulfide-stabilized polypeptide fragments having bi does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Recombinant disulfide-stabilized polypeptide fragments having bi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant disulfide-stabilized polypeptide fragments having bi will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-56140