Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1980-04-03
1983-01-25
Marantz, Sidney
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
260112R, 435172, 435215, 536 27, C12P 2100, C12N 1500
Patent
active
043704174
ABSTRACT:
The present invention provides a deoxyribonucleic acid (DNA) segment related to a human plasminogen activator gene. The segment is inserted into a plasmid vector which in turn can be incorporated into a bacterium or other microorganism. The bacterium can then be cultured to produce a plasminogen activator protein having properties of human urokinase.
REFERENCES:
patent: 3355361 (1967-11-01), Lesuk
patent: 3755083 (1973-08-01), Novak
patent: 3957582 (1976-05-01), Stried
patent: 4190495 (1980-02-01), Curtiss
patent: 4237224 (1980-12-01), Cohen
Chang et al., Nature, vol. 275, 617-622, (Oct. 1978).
Chen Michael C.
Hung Paul P.
Lee Shaw-Guang
Ratzkin Barry J.
Roychoudhury Ranajit
Abbott Laboratories
Fato Gildo E.
Marantz Sidney
Niblack Robert L.
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