Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...
Patent
1995-06-06
1998-11-03
Fleisher, Mindy
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
4351723, 4353201, 536 231, 536 237, 536 241, C12N 701, C12N 1500, C12N 1511, C12N 1586
Patent
active
058307451
ABSTRACT:
The present invention provides a virus comprising a DNA sequence essential for replication of a human cytomegalovirus and at least one foreign DNA sequence adapted for expression in a host. The foreign DNA sequence may encode a human immunodeficiency virus anti-sense mRNA sequence or an antigenic polypeptide, e.g., a malarial surface antigen. Also provided are therapeutic compositions and vaccines which comprise the novel viruses of the present invention.
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patent: 5273876 (1993-12-01), Hock et al.
patent: 5385839 (1995-01-01), Stinski
patent: 5561063 (1996-10-01), Hock et al.
Foecking et al. "Poweful & Versatile Enhancer-Promoter Unit for Gammalian Expression Vectors" Mene 45 1986 101-105.
Thomsen et al. "Promoter Regulatory Region of the Major Immediate Ealy Gene of Human Cytomegalovirus" PNAS 81659-663 1984.
Tamashiro et al. "Constructing a Library of the ELori Fragments . . . " J. Vhol. 42(2) 547-557 1982.
Cochran Mark D.
Hock Lisa J.
MacDonald Richard D.
Degen Nancy J.
Fleisher Mindy
Syntro Corporation
White John P.
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