Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1994-11-15
1996-08-20
Mosher, Mary E.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 693, 4351721, 4241861, 4242301, 935 65, 530350, C12Q 170, C07K 14045
Patent
active
055478344
ABSTRACT:
The present invention provides recombinant polypeptides derived from CMV glycoprotein gB and truncated fragments thereof which contain at least one epitope which is immunologically identifiable with one encoded by the CMV genome. The complete characterization of the gB protein, including the identity of glycoprotein gp55, permits the production of polypeptides which are useful as standards or reagents in diagnostic tests and/or as components of vaccines. This invention provides recombinant polypeptides and recombinant polynucleotides encoding these polypeptides wherein a neutralizing epitope of gB is localized within gp55.
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Pachl Carol A.
Spaete Richard R.
Blackburn Robert P.
Chiron Corporation
McClung Barbara G.
Mosher Mary E.
Robins Roberta L.
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