Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant virus encoding one or more heterologous proteins...
Patent
1994-12-22
1999-10-12
Knode, Marian C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant virus encoding one or more heterologous proteins...
4241861, 4242011, 4242021, 4242041, 4242141, 4242291, 4242221, 4353201, 435 691, 4352351, 4352401, 4352402, 536 2372, 536 242, 536 2351, 536 2352, 536 232, A61K 3912, A61K 39295, C12N 1500, C12P 2106
Patent
active
059651385
ABSTRACT:
This invention provides a recombinant herpesvirus of turkeys comprising a herpesvirus of turkeys viral genome which contains a foreign DNA sequence inserted within the EcoR1 #9 fragment of the herpesvirus of turkeys viral genome, and the foreign DNA sequence is capable of being expressed in a host cell infected with the herpesvirus of turkeys.
This invention provides a recombinant herpesvirus of turkeys-Marek's disease virus chimera comprising a herpesvirus of turkeys unique long viral genome region and a Marek's disease virus unique short region.
Lastly, this invention provides homology vectors for producing a recombinant herpesvirus of turkeys, host cells, and vaccines and methods for immunization.
REFERENCES:
patent: 4859587 (1989-08-01), Roizman
patent: 4877737 (1989-10-01), Shih et al.
patent: 5047237 (1991-09-01), Cochran
patent: 5171677 (1992-12-01), Sakaguchi et al.
patent: 5187087 (1993-02-01), Sondermeijer et al.
patent: 5223424 (1993-06-01), Cochran et al.
patent: 5225336 (1993-07-01), Paolietti
patent: 5240703 (1993-08-01), Cochran
patent: 5252717 (1993-10-01), Velicer et al.
patent: 5266489 (1993-11-01), Rey-Senelonge et al.
Cantello, J., et al. (1991) "Isolation of a Marek's Disease Virus (MDV) Recombinant Containing the lacZ Gene of Escherichia coli", J. Virology 65:1584-1588.
Chen, X., et al. (1992) "Identification of a Unique Marek's Disease Virus Gene Which Encodes a 38-Kilodalton Phosphoprotein and Is Expressed in both Lytically Infected Cells and Latently Infected Lymphoblastoid Tumor Cells", J. Virology 66:85-94.
Gibbs, C., et al. (1984) "Extensive Homology Exists between Marek Disease Herpesvirus and its Vaccine Virus, Herpesvirus of Turkeys", Proc. Natl. Acad. Sci. USA 81:3365-3369.
Igarashi, T., et al. (1987) "Restriction Enzyme Map of Herpesvirus of Turkey DNA and Its Collinear Relationship with Marek's Disease Virus DNA", Virology 157:351-358.
Kaschka-Dierich, C., et al. (1979) "No Homology Detectable between Marek's Disease Virus (MDV) DNA and Herpesvirus of the Turkey (HVT) DNA", Med. Microbiol. Immunol. 165:223-239.
Kato, A., et al. (1989) "Homologies between Herpesvirus of Turkey and Marek's Disease Virus Type-1 DNAs within Two Co-linearly Arranged Open Reading Frames, One Encoding Glycoprotein A", Gene 84:399-405.
Lee, Y-S., et al. (1979) "Minor DNA Homology between Herpesvirus of Turkey and Marek's Disease Virus?", Virology 93:277-280.
Morgan, R., et al. (1992). "Protection of Chickens from Newcastle and Marek's Diseases with a Recombinant Herpesvirus of Turkeys Vaccine Expressing the Newcastle Disease Virus Fusion Protein", Avian Diseases 36:858-870.
Ross, L., et al. (1991) "DNA Sequence and Organization of Genes in a 5.5 kbp EcoRI Fragment Mapping in the Short Unique Segment of Marek's Disease Virus (Strain RB1B)", J. General Virology 72:949-954.
Ross, L., et al. (1991) "Properties and Evolutionary Relationships of the Marek's Disease Virus Homologues of Protein Kinase, Glycoprotein D and Glycoprotein I of Herpes Simplex Virus", J. General Virology 72:939-947.
Weber, P., et al. (1987) "Rapid Identification of Nonessential Genes of Herpes Simplex Virus Type 1 by Tn5 Mutagenesis", Science 236:576-579.
Reilly, David J. and Silva, Robert F. (1993) "Cosmid library of the turkey herpesvirus genome constructed from nanogram quantities of viral DNA associated wiyj an excess of cellular DNA", J. Virological 41:323-332 (Ex. 4).
Sondermeijer, Paul J.A. et al. (1993) "Avian herpesvirus as a live viral vector for the expression of heterologous antigens", Vaccine, vol. 11, Issue 3 (Ex. 5).
Ross, L.J.N., et al. (1993) "Construction and properties of a turkey herpesvirus recombinant expressing the Marek's disease virus homologue of glycoprotein B of herpes simplex virus", 7 J.Virology 74, 371-377 (Ex. 6).
Scott, Simon D., et al. (1993) "Identification and sequence analysis of the homologues of the herpes simplex virus type 1 glycoprotein H in Marek's disease virus and the herpesvirus of turkeys", J.Virology 74, 1185-1190 (Ex. 7).
Marshall, D.R., et al. (1993) "Selection of Marek's Disease Virus Recombinants Expressing the Escherichia coli gpt Gene", Virology 195, 638-648 (Ex. 8).
Zelnik, V., et al. (1993) "The complete sequence and gene organization of the short unique region of herpesvirus of turkeys", J. Virology 74, 2151-2162 (Ex. 9).
Morgan, Robin W., et al. (1993) "Efficacy in chickens of a herpesvirus of Turkeys Recombinant Vaccine Containing the Fusion Gene of Newcastle Disease Virus: Onset of Protection and Effect of Maternal Antibodies", Avian Diseases 37:1032-1040 (Ex. 10).
Lindenmaier, W. and Bauer, H.J. (1994) "Cosmid cloning and restriction endonuclease mapping of the herpesvirus of turkeys (HVT) genome", Arch Virol 135:171-177 (Ex. 11).
Zelnik, V., et al. (1994) "Characterization of proteins encoded by the short unique region of herpesvirus of turkeys by in vitro expression", J. Virology 75,2747-2753 (Ex. 12).
Parcells, Mark S., et al. (1994) "Characterization of a Marek's Disease Virus Mutant Containing a LacZ Insertion in the USA (gD) Homologue Gene", Virus Genes 9:1,5-13 (Ex. 13).
Petrovskis, Erik A., et al. (1986) "Deletions in Vaccine Strains of Pseudorabies Virus and Their Effect on Synthesis of Glycoprotein gp63", J. Virology pp. 1166-1169 vol. 60 No.3 (Ex. 14).
Ben-Porat, T., et al. (1986) "Role of Glycoproteins of Pseudorabies Virus in Eliciting Neutralizing Antobodies", Virology 154, 325-334 (Ex. 15).
Price, Richard W., and Khan, Atia; (1981) "Resistance of Peripheral Autonomic Neurons to In Vivo Productive Infection by Herpes Simplex Virus Mutants Deficient in Thymidine Kinase Activity", Infection and Immunity, pp. 571-580, vol.34 No.2 (Ex. 16).
Tenser, Richard B., et al. (1983) "The Role of Pseudorabies Virus Thymidine Kinase Expression in Trigeminal Ganglion Infection", J.Gen. Virol. 64, 1369-1373 (Ex. 17).
Lomniczi, Bela, et al. (1984) "Deletions in the Genomes of Pseudorabies Virus Vaccine Strains and Existence of Flour Isomers of the Genomes", J.Virology pp. 970-979; vol.49 No.3 (Ex. 18).
Thomsen, Darrell R., et al. (1987) "Pseudorabies virus as a live virus vector for expression of foreign genes", Gene 57, 261 265 (Ex. 19).
Honess, R.W., (1984) "Herpes Simplex and `The Herpes Complex`: Diverse Observations and A Unifying Hypothesis", J. Gen. Virol. 65,2077-2107 (Ex. 20).
Cook, Margery L. and Stevens, J.G., (1976) "Latent Herpetic Infections Following Experimental Viraemia", J.Gen. Virol. 31, 75-80 (Ex. 21).
Thompson, R.L., et al. (1983) "Physical Location of a Herpes Simplex Virus Type-1 Gene Function(s) Specifically Associated with a 10 Million-Fold Increase in HSV Neurovirulence", J. Virology 131, 180-192 (Ex. 22).
Fukuchi, K., et al. (1985) "The Structure of Marek disease virus DNA: The presence of unique expansion in nonpathogenic viral DNA", Proc.Natl.Acad.Sci.USA vol.82, pp. 751-754 (Ex. 23).
Koomey, Michael J., et al. (1984) "Deletion of DNA Sequences in a Nononcogenic Variant of Herpesvirus saimiri", J.Virol. pp. 662-665, vol.50 No.2 (Ex. 24).
Spaete, Richard R. and Mocarski, Edward S., (1987) "Insertion and deletion mutagenesis of the human cytomegalovirus genome", Proc.Natl.Acad.Sci.USA vol.84, pp. 7213-7217 (Ex. 25).
Shih, Meng-Fu, et al. (1984) "Expression of hepatitis B virus S gene by herpes simplex virus type 1 vectors carrying .alpha.- and .beta.-regulated gene chimeras", Proc.Natl.Acad.Sci.USA vol.81, pp. 5867-5870 (Ex. 26).
Edwards, Stirling J., (1988) "Plasmodium Falciparum Antigens In Recombinant HSV-1", Technological Advances in Vaccine Development, p. 223-234 (Ex. 27).
Roizman, Bernard, et al. (1983) "Bioengineering of Herpes Simplex Virus Variants for Potential Use as Live Vaccines", Cold Spring Harbor Conference on New Approaches to Virla Vaccines, pp. 275-281 (Ex. 28).
Moss, Bernard, (1991) "Vaccinia Virus: A Tool for Research and Vaccine Development", Science 252:1662-1667 (Ex. 29).
Weir, Jerry P., and Narayanan, P.R., (1988) "The use of .beta.-galactosidase as a marker gene to define the regulatory sequences of the herpes simplex virus type 1 glycoprotein C gene in recombinant herpesviruses", Nucleic
Cochran Mark D.
Junker David E.
Singer Phillip A.
Wild Martha A.
Knode Marian C.
Salimi Ali R.
Syntro Corporation
White John P.
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