Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Reexamination Certificate
2009-05-18
2011-10-04
Graser, Jennifer (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
C424S269100, C424S185100, C424S192100, C435S007100, C435S007200, C435S007320, C530S350000
Reexamination Certificate
active
08029804
ABSTRACT:
Recombinant chimeric antigens comprising unmodified and modified reactive polypeptide fragments of expressed product of the recombinant 56 kDa proteins of multiple strain of scrub typhus, such as Karp, Kato (Ktr56), Gilliam (Gmr56), and TA763 (TAr56). The invention is useful for detecting prior exposure to a number of strains of scrub typhus, based on the strength of reaction toward the chimeric protein and as a component in vaccine formulations and production of immune globulins for passive prophylaxis and immunity in subjects against heterologous infections.
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Chothia et al (The EMBO Journal, 1986, 5/4:823-26).
Chao Chien-Chung
Ching Wei-Mei
Churilla Albert M.
Graser Jennifer
Hemby, Jr. Joseph K.
The United States of America as represented by the Secretary of
Yang Ning
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