Recombinant canine adenovirus 2 (CAV-2)

Details Recombinant canine adenovirus 2 (CAV-2) Recombinant canine adenovirus 2 (CAV-2)

1994-05-23

1997-04-01

Caputa, Anthony C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant virus encoding one or more heterologous proteins...

4242051, 4242331, 424818, 424819, 4242241, 4242071, 4242081, 4352351, 4352523, 4353201, A61K 39235, A61K 39205, A61K 3921, C12N 701, C12N 1547, C12N 1548, C12N 1549

Patent

active

056163266

ABSTRACT:
A non-essential region in strains of live non-pathogenic immunogenic canine adenovirus is described. The insertion of genes from pathogenic carnivora viruses into this region, with suitable expression control systems, without prejudicing the stable reproducibility of the adenovirus vector is described. Such recombinant canine adenoviruses modified to contain a gene coding for an antigen or immunogenic agent, in association with an effective promoter for the gene, are described.

REFERENCES:
patent: 4920209 (1990-04-01), Davis et al.
N. Spibey, et al; Identification and nucleotide sequence of the early region 1 from canine adenovirus types 1 and 2; Virus Research 14, pp. 241-256 (1989).
M. Shinagawa, et al; Phylogenetic relationships between adenoviruses as inferred from nucleotide sequences of inverted terminal repeats; Gene 55 pp. 85-93 (1987).
KC Chow, In Vitro Adenovirus DNA Replication; Diss Abstr Int (Sci) 45(10 3223B (1985).
K. Wang and G.D. Pearson; Adenovirus sequences required for replication in vivo; Nucl. Acids Res. 13(14) pp. 5173-5187 (1985).
F.L. Graham; Adenoviruses as expression vectors and recombinant vaccines, Trends in Biotechnology 8, pp. 85-87 (Apr. 1990).

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