Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Heavy metal or compound thereof
Reexamination Certificate
2006-04-25
2006-04-25
Weber, Jon (Department: 1653)
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Heavy metal or compound thereof
C424S600000, C530S400000, C530S350000, C428S326000, C428S669000, C435S440000, C514S002600
Reexamination Certificate
active
07033613
ABSTRACT:
Using a gene recombination technique, a glutamic acid and an aspartic acid positioned in a channel of apoferritin are substituted with serine having a small size and no charges. Then, a glutamic acid positioned in a holding portion is substituted with a basic amino acid such as lysine or a neutral amino acid. Furthermore, at least one cysteine is introduced into the holding portion. This prevents a repulsive force due to electrostatic interaction between (AuCl4)−having a negative charge and a negative amino acid from occurring, which facilitates the capture of (AuCl4)−into the channel and the holding portion. The (AuCl4)−captured into the holding portion is subsequently reduced to Au, and thus apoferritin including gold particles can be produced.
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Harness & Dickey & Pierce P.L.C.
Liu Samuel W.
Weber Jon
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