Recombinant C140 receptor, its agonists and antagonists, and nuc

Details Recombinant C140 receptor, its agonists and antagonists, and nuc Recombinant C140 receptor, its agonists and antagonists, and nuc

1995-06-07

1999-02-23

Guzo, David

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

435 71, 435 72, 5303871, 5303881, 5303882, 5303913, A61K 39395, C07K 1628, G01N 3353

Patent

active

058744002

ABSTRACT:
Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which can be produced on the surface of a cell, including an oocyte. The nucleic acid molecules are useful in an assay for detecting a substance which affects C140 receptor activity, either receptor agonists or antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in such assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with one or more antigenic epitopes of the C140 receptor.

REFERENCES:
patent: 5128254 (1992-07-01), Sibley et al.
Patel et al. "Mini Review: The Somatostatin Receptor Family," Life Sciences 5(13) 11 Jul. 1995:1249-1265.
Horuk, "Molecular properties of the chemokine receptor family," TiPS May 1994, 151(5):159-165.
R. J. Kaufman, Methods in Enzymology, vol. 185, pp. 487-511 (1990): "Vectors Used for Expression in Mammalian Cells".
Masu et al., Nature, vol. 329, pp. 836-838 (1987): "cDNA Cloning of Bovine Substance-K Receptor Through Oocyte Expression System".
Scarborough et al., The Journal of Biological Chemistry, vol. 267 (19):13146-49 (1982): "Tethered Ligand Agonist Peptides".
Vu et al., Cell, vol. 64, pp. 1057-1068 (1991): "Molecular Cloning of a Functional Thrombin Receptor Reveals a Novel Proteolytic Mechanism of Receptor Activation".

Affiliated with

Also associated with

Rating

Recombinant C140 receptor, its agonists and antagonists, and nuc does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Recombinant C140 receptor, its agonists and antagonists, and nuc, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant C140 receptor, its agonists and antagonists, and nuc will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-306876