Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1993-07-26
1997-05-13
Guzo, David
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4351723, 4353201, 435325, 536 235, C12P 2102, C12N 510, C12N 1563
Patent
active
056291744
ABSTRACT:
The DNA encoding the C140 cell surface receptor has been cloned and sequenced. The availability of this DNA permits the recombinant production of the C140 receptor which can be produced at cell or oocyte surfaces and is useful in assay systems both for the detection of substances which affect its activity, including agonists and antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in these assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with the receptor per se or with specific regions thereof.
REFERENCES:
patent: 5128254 (1992-07-01), Sibley et al.
Masu et al. "cDNA Cloning of Bovine Substance-K Receptor Through Oocyte Expression System", Nature, vol. 328, 29 Oct. 1987, pp. 836-838.
Kaufman, "Vectors Used for Expression in Mammalian Cells", Methods in Enzymology, vol. 185, 1990, pp. 487-511.
Scarborough et al., "Tethered Ligand Agonist Peptides", The Journal of Biological Chemistry 267(19):13146-49 (1992).
Scarborough Robert M.
Sundelin Johan
COR Therapeutics Inc.
Guzo David
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