Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2002-05-28
2010-02-02
Rawlings, Stephen L (Department: 1643)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
Reexamination Certificate
active
07655759
ABSTRACT:
The present invention relates to fragments, especially variable fragments of immunoglobulins which are by nature devoid of light chains, these fragments being nevertheless capable of exhibiting a recognition and binding activity toward specific antigens. The present invention further relates to the use of such immunoglobulin fragments formed of at least one heavy chain variable fragment or derived therefrom, for therapeutic or veterinary purposes and especially for passive immunotherapy or serotherapy.
REFERENCES:
patent: 4689299 (1987-08-01), Insel et al.
patent: 5124249 (1992-06-01), Khan et al.
patent: 5316911 (1994-05-01), Baek et al.
patent: 5719267 (1998-02-01), Carroll et al.
patent: 5989830 (1999-11-01), Davis et al.
patent: 6005079 (1999-12-01), Casterman et al.
patent: 6103521 (2000-08-01), Capon et al.
patent: 6165745 (2000-12-01), Ward et al.
patent: 6225447 (2001-05-01), Winter et al.
patent: 6365158 (2002-04-01), Williams et al.
patent: 6517829 (2003-02-01), Frenken et al.
patent: 6610472 (2003-08-01), Zhu et al.
patent: 2004/0253638 (2004-12-01), Casterman et al.
patent: WO 93 01288 (1993-01-01), None
patent: WO 94 04678 (1994-03-01), None
patent: WO 94 25591 (1994-11-01), None
Oguma et al (Infection and Immunity 38:14-20, 1982).
Els Conrath et al. (J. Biol. Chem. Mar. 9, 2001; 276 (10): 7346-7350).
Mallender et al. (J. Biol. Chem. Jan. 7, 1994; 269 (1): 199-206).
Arbabi Ghahroudi et al. (FEBS Lett. 1997; 414: 521-526).
Mullinax et al., “Identification of Human Antibody Fragment Clines Specific For Tetanus Toxoid In A Bacteriophage Lambda Immunoexpression”, Proceedings of the National Academy of Sciences of the USA, vol. 87, No. 20, pp. 8095-8099, Oct. 1990.
Muyldermans et al., “Sequence and Structure Of Vh Domain From Naturally Occurring Camel Heavy Chain Immunoglobulins Lacking Light Chains”, Protein Engineering, vol. 7, No. 9, pp. 1129-1135, (1994).
Davies et al., “Camelising Human Antibody Fragements: NMR Studies on VH Domains”, FEBS Letters, Vo. 339, No. 3, pp. 285-290, (1994).
Paul-Murphy et al., “Immune Response Of The Llama (Lama Glama) to Tetanus Toxoid Vaccination”, American Journal Of Veterinary Research, Vo. 50, No. 8, pp. 1279-1281, (Aug. 1989).
Davies et al., “Antibody VH Domains As Small Recognition Units”, Bio/Technology, vol. 13, No. 5, pp. 475-479, (May 1995).
Cruse et al., Illustrated Dictionary Of Immunology, CRC Press, pp. 38 and 143-144.
Hamers-Casterman et al., Nature 363, pp. 446-448, (1993).
Panka et al., Proc. Natl. Acad. Sci. USA 85, pp. 3080-3084, (1988).
Rudikoff et al., Proc. Natl. Acad. Sci. USA. 79, pp. 1979-1983, (1982).
Amit et al., Science 233, pp. 747-753, (1986).
Borrebaeck et al., (1992)Bio/Technology10, 697-698.
Casali et al., (1989)Annu. Rev. Immunol. 7, 513-535.
Friguet et al., (1983)J. Immunol. Meth. 60, 351-358.
Friguet et al., (1990) In: Protein Structure. A practical approach (Ed. T.E. Creighton) IRL Press, p. 287-310.
Glockshuber et al., (1990)Biochemistry29, 1362-1367.
Hoogenboom et al., (1991)Nucl. Acids Res. 19, 4133-4137.
Johnson, W.C., (1990)Proteins: Structure, Func.&Genetics7, 205-214.
Marks et al., (1991)J. Mol. Biol. 222, 581-597.
Montecucco & Schiavo, (1993)TIBS18, 324-329.
Persson et al., (1991)Proc. Natl. Acad. Sci. USA88, 2432-2439.
Simpson et al., (1990)J. Pharmacol.&Exp. Therap. 254(1): 98-103.
Skerra & Pluckthun, (1988)Science240, 1038-1040.
Arturson, G. et al., “Intravascular Persistence and Renal Clearance of Dextran of Different Molecular Sizes in Normal Children,”Arch. Dis. Childh. 1966; 41:168-171.
Knauf, M. J. et al., “Relationship of Effective Molecular Size to Systemic Clearance in Rats of Recombinant Interleukin-2 Chemically Modified with Water-soluble Polymers,”The Journal of Biological Chemistry1988; 263(29):15064-15070.
Hamers Raymond
Muyldermans Serge
Rawlings Stephen L
Vrije Universiteit Brussel
Wolf Greenfield & Sacks P.C.
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