Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2009-12-31
2011-10-25
Duffy, Patricia A (Department: 1645)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S476000, C435S489000, C435S490000
Reexamination Certificate
active
08043857
ABSTRACT:
Mycobacteriumstrains that have an enhanced ability to elicit a MHC-Class I-restricted CD8+T cell immune response are provided. TheMycobacteriumstrains are genetically engineered to express: a endosomalytic protein that is active at neutral pH (e.g. Perfringolysin O), permitting escape of theMycobacteriumfrom endosomes into the cytoplasm of the cell; and antigens of interest, such as tuberculosis antigens. The invention also provides vaccine preparations containing suchMycobacteriumstrains.
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Hone David Michael
Sadoff Jerald C.
Sun Ronggai
Aeras Global TB Vaccine Foundation
Duffy Patricia A
Whitham Curtis Christofferson & Cook PC
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