Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Reexamination Certificate
2007-05-31
2010-02-23
Duffy, Patricia A (Department: 1645)
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
C435S252300, C424S093200, C424S093400, C424S248100
Reexamination Certificate
active
07666656
ABSTRACT:
Mycobacteriumstrains that have an enhanced ability to elicit a MHC-Class I-restricted CD8+T cell immune response are provided. TheMycobacteriumstrains are genetically engineered to express: a endosomolytic protein that is active at neutral pH (e.g. Perfringolysin O), permitting escape of theMycobacteriumfrom endosomes into the cytoplasm of the cell; and antigens of interest, such as tuberculosis antigens. The invention also provides vaccine preparations containing suchMycobacteriumstrains.
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Hone David Michael
Sadoff Jerald C.
Sun Ronggai
Aeras Global TB Vaccine Foundation
Duffy Patricia A
Whitham Curtis Christofferson & Cook PC
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