Recombinant baculovirus occlusion bodies in vaccines and biologi

Details Recombinant baculovirus occlusion bodies in vaccines and biologi Recombinant baculovirus occlusion bodies in vaccines and biologi

1988-02-08

1989-09-26

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Vector, per se

435 68, 435 91, 4351723, 435235, 435243, 536 27, 935 32, 935 57, 935 70, 530350, 530820, 530826, C12N 700, C12N 1500, C12N 100, C12P 2100

Patent

active

048700231

ABSTRACT:
The present invention is directed to recombinant baculoviruses which encode fusion polyhedrin proteins capable of forming occlusion bodies containing foreign peptides. The recombinant baculoviruses of the invention are formed by insertion into or replacement of regions of the polyhedrin gene that are not essential for occlusion body formation, with foreign DNA fragments by recombinant DNA techniques. The recombinant occlusion bodies produced in accordance with the present invention have uses in vaccine formulations, immunoassays, immobilized enzyme reactions, as biological insecticides, and as expression vectors.

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