Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2005-02-08
2005-02-08
Guzo, David (Department: 1636)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S235100, C435S320100, C435S455000, C435S456000, C435S069600, C435S069700, C435S069800, C435S325000, C435S348000, C530S350000, C530S387100, C530S387300, C536S023100, C536S023400, C536S023500, C536S024100
Reexamination Certificate
active
06852507
ABSTRACT:
Recombinant baculovirus used as an expression vector in the production of immunoglobulins with an insect cell. The invention is characterized by a first expression cassette comprising a first sequence coding for at least one portion of an immunoglobulin heavy chain, wherein the sequence is transcriptionally controlled by a first baculovirus promoter, and a second expression cassette comprising a second sequence coding for at least one portion of an immunoglobulin light chain, said second sequence being transcriptionally controlled by a second baculovirus promoter. The first and second promoters are two different promoters or derivatives of different promoters, the first and second promoters residing at different loci.
REFERENCES:
patent: 5229272 (1993-07-01), Paul et al.
patent: 6312690 (2001-11-01), Edelman et al.
Carayannopoulos et al., PNAS, Aug. 1994, vol. 91, pp. 8348-8352.*
Charles A. Hasemann et al, High-level production of a functional immunoglobulin heterodimer in a baculovirus expression system, vol. 87, pp. 3942-3946, May 1990.
Cerutti Martine
Chaabihi Hassan
Devauchelle Gerard
Gauthier Laurent
Kaczorek Michel
Guzo David
L'Institut National de la Recherche Agronomique
Le Centre National de la Recherche Scientifique
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