Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-10-25
2005-10-25
Chen, Shin-Lin (Department: 1632)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S350000
Reexamination Certificate
active
06958318
ABSTRACT:
The present invention provides a procaryotic host cell stably transformed or transfected by a vector including a DNA sequence encoding for purine nucleoside phosphorylase or hydrolase. The transformed or transfected procaryotic host cell can be used in combination with a purine substrate to treat tumor cells and/or virally infected cells.
REFERENCES:
patent: 5552311 (1996-09-01), Sorscher et al.
patent: 0 415 731 (1991-03-01), None
patent: 0 392 745 (1994-11-01), None
Eck et al., 1996, Goodman & Gilman=s The Pharmacological Basis of Therepeutics, McGraw-Hill, New York, p. 77-101.
Rudinger, 1976, Peptide Hormones, Edited by Parsons, University Park Press, Baltimore, p. 1-7.
Kaye et al., 1990, Proc. Natl. Acad. Sci. USA, vol. 87, pp. 6922-6926.
Skolnick et al., 2000, Trends in Biotech, vol. 18, p. 34-39.
Sorscher et al., 1994, Gene therapy, vol. 1, No. 4, p. 233-238.
Allen (1989) Stealth(TM) Liposomes: Avoiding Reticuloendothelial uptake. Liposomes in the Therapy of Infectious Diseases and Cancer, pp. 405-415.
Anderson (1992) Human Gene Therapy. Science, 256:808-813.
Bagshawe (1989) Towards generating cytotoxic agents at cancer sites. J. Cancer, 60:275-281.
Balzarini et al. (1993) J. Biol. Chem., 268(9):6332-6337.
Barankiewicz and Jezewska (1976) Inosine-guanosine and adenosine phosphorylase activities in hepatopancrease of helix pomatia (gastropoda). Comp. Biochem. Physiol., vol. 54B, pp. 239-242.
Bennett et al. (1984) Mode of action of a-amino-6-chloro-1-dexzapurine. Biochemical Pharmacology, vol. 33, No. 2, ppl 261-271.
Bohman et al. (1983) Mechanism of cytostatic action of novel 5-(Thien-2-yl) and 5-Furan-2yl)-substituted pyrimidine nucleoside analogues against tumor cells transfected by the thymidine kinase gene of herpes simplex virus. The Journal of Biological Chemistry, vol. 269, No. 11, ppl. 8036-8043.
Brockman et al. (1980) Metabolism and chemotherapeutic activity of 9-3-D-Arabinofuranosyl-2-fluoroadenine against murine leukemia L1210 and evidence for its phosphorylation by deoxycytidine kinase. Cancer Research, 40:3610-3615.
Bruce and Meeker (1967) J. Natl. Cancer Inst., 38:401-405.
Burland et al. (1995) Analysis of theEscherichia coligenome VI: DNA sequence of the region from 92.8 through 100 minutes. Nucleic Acids Research, vol. 23, No. 12, pp. 2105-2119.
Carson et al. (1980) Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo. Proc. Natl. Acad. Sci. USA, vol. 77, No. 11, pp. 6865-6869.
Collier (1988) Structure-activity relationship in andPseudomonas aeruginosaexc. In Immunotoxins, A.E. Frankel, Ed. (Kluwer Academic Publishers, Boston), pp. 25-35.
Conners (1995) The choice of prodrugs for gene directed enzyme prodrug therapy of cancer. Gene Therapy, 2:702-709.
Culver et al. (1991) In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Proc. Natl. Acad. Sci. USA, 88:3155-3159.
Culver et al. (1992) Lymphocytes as cellular vehicles for gene therapy in mouse and man. Science, 256:1550-1552.
Culver et al. (1994) Gene therapy for cancer. Trends in Genetics, 10:174-178.
Curiel et al. (1992) High-efficiency gene transfer by adenovirus coupled to DNA-polylsine complexes. Hum. Gene Ther., 3:147-154.
Da Costa et al. (1996) Converting cancer genes into killer genes. Proc. Natl. Acad. Sci. USA, 93:4192-4196.
Dadonna et al. (1986) Expression of human malaria parasite purine nucleoside phosphorylase in host enzyme-deficient erythrocyte culture. The Journal of Biological Chemistry, vol. 261, No. 25, Issue of Sep. 5, pp. 11667-11673.
Debs et al. (1987) Selective enhancement of pentamidine uptake in the lung by aerosolization and delivery in liposomes. Am. Rev. Respir. Dis., 135:731-737.
Dewey and Kidder (1973) Partial purification and properties of a nucleoside hydrolase from crithidia. Archives and Biochemistry and Biophysics, 157:380-387.
Doskocil and Holy (1977) Specificity of purine nucleoside phosphorylase fromEscherichia coli. Collection Czechoslov. Chem. Commun., 42:370-383.
Dykes et al. (1992) Development of human tumor zenograft models for in vivo evaluation of new antitumor drugs. Contri. Oncol. Basel, Karger, 42:1-22.
Ealick et al. (1990) Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2 A resolution. The Journal of Biological Chemistry, vol. 265, No. 3, pp. 1812-1820.
Fox et al. (1996) Anaerobic bacteria as a delivery system for cancer gene therapy: in vitro activation of 5-fluorocytosine by genetically engineered clostridia. Gene Therapy, 9:173-178.
Freeman et al. (1996) In situ use of suicide genes for cancer therapy. Seminars in Oncology, 23:31-45.
Freireich et al. (1966) Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man. Cancer Chemotherapy Reports, vol. 50, No. 4, pp. 219-244.
Freidmann (1989) Progress toward human gene therapy. Science, 244:1275-1281.
Gabizon and Papahadiopoulos (1988) Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors. Proc. Natl. Sci. USA, 85:6949-6953.
Garver et al. (1994) Strategy for achieving selective killing of carcinomas. Gene Therapy L, 46-50.
Gay (1984) Construction and characterization of anEscherichia colistrain with a uncI mutations. J. Bacteriol, 158:820-825.
Ghoda et al. (1988) Substrate specification of 5′-deoxy-5′-methylthioadenosine phosphorylase fromTrypanosoma brucei bruceiand mammalian cells. Molecular and Biochemical Parasitology, 27:109-118.
Giebel et al. (1991) Organization and nucleotide sequences of the human tyrosinase gene and a truncated tyrosinase-related segment. Genomics, 9:435-445.
Gutteridge and Davies (1981) Enzymes of purine salvage in trypanosoma cruzi. FEBS Letters, vol. 127, No. 2, pp. 21-24.
Hatanka et al. (1975) Adenine formation from adenosine by mycoplasmas: adenosine phosphorylase activity. Proc. Natl. Acad. Sci. USA, 72:1401-1405.
Hershfield et al. (1991) Use of site-directed mutagenesis to enhance the epitope-shielding effect of covalent modification of proteins with polyethylene glycol. Proc. Natl. Acad. Sci. USA, 88:7185-7189.
Heyworth et al. (1982) Purine metabolism in trichomonas vaginalis. FEBS Letters, vol. 1, No. 1, pp. 106-110.
Hooper and Subak-Sharpe (1981) Metabolic cooperation between cells. Internat'l Rev. of Cytol., 69:45-104.
Houston (1988) Introduction. In Immunotoxins. A.E. Frankel, Ed (Kluwer Academic Publishers, Boston) pp. 1-7.
Huang et al. (1992) Pharmacokinetics and therapeutics of sterically stabilized liposomes in mice bearing C-26 colon carcinoma. Cancer Research, 52:6774-6781.
Huber et al. (1991) Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy. Proc. Acad. Sci. USA, 88:8039-8043.
Hughes et al. (1995) Bystander killing of melanoma cells using the human tyrosinase promoter to express theEscherichia colipurine nucleoside phosphorylase gene. Cancer Research, 55:3339-3345.
Jensen (1978) Two purine nucleoside phosphorylases in bacillus subtilis purification and some properties of the adenosine-specific phosphorylase. Biochimica et Biophysics Acta, 525:346-356.
Jensen and Nygaard (1975) Purine nucleoside phosphorylase fromEscherichia coliandSalmonella typhimurium. Eur. J. Biochem., 51:253-265.
Jenuth and Snyder (1991) Nucleotide sequence of murine purine nucleoside phosphorylase cDNA. Nucleic Acids Research, vol. 19, No. 7, p. 1708.
Jiao et al. (1993) Long-term correction of rat model of Parkinson's disease by gene therapy. Nature, 362:450-453.
Kidder et al. (1979) The purine phosphoribosyltransferases of crithidia fasciculata. J. Parasitol., 64(4), pp. 520-525.
Kikuchi et al. (1989) Characteristic sequences in the upstream region of the human tyrosinase gene. Biochimica at Biophysica Acta., 1009:283-286.
Kolls et al. (1994) Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer. Proc. Natl. Acad. Sci, USA, vol. 91, pp. 215-219.
Kolata (Jul. 25, 1995) The New York
Bennett, Jr. Leonard L.
Gadi Vijayakrishna K.
Parker William B.
Sorscher Eric J.
Waud William
Chen Shin-Lin
Gifford, Krass, Groh Sprinkle, Anderson & Citkowski, P.C.
Southern Research Institute
The UAB Research Foundation
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