Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Reexamination Certificate
2005-08-09
2005-08-09
Priebe, Scott D. (Department: 1632)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
C424S093400, C424S093480, C424S405000, C435S252300, C435S471000
Reexamination Certificate
active
06926889
ABSTRACT:
The present invention relates to recombinant bacteria genetically engineered from insect hosts to express toxic gene products in a pest insect. The present invention also relates to a method of controlling an insect population using such a recombinant bacteria as a delivery agent throughout an insect colony. The invention also relates to a method of delivering and expressing a gene in an insect.
REFERENCES:
patent: WO 9402591 (1994-02-01), None
Watanabe et al., “Biological control of an insect pest by gut colonizing Enterobacter clacoe transformed with ice nucleation gene,” J. Appl. Microbiol. 88(1): 90-97, Jan. 2000.
Thanabalu et al., “Expression of the mosquitocidal toxins of Bacillus sphaericus and Bacillus thuringensis subsp. israelensis by recombinant Caulobacter crescentus. . .”, Appl. Environ. Microbiol. 58(3): 905-910, Mar. 1992.
Liu et al., “Efficient synthesis of mosquitocidal toxins in Asticcacaulis excentricus demonstrates potential of gram-negative bacteria in mosquito control,” Nat. Biotech. 14(3): 343-347, Mar. 1996.
Khampang et al., “Efficient expression of mosquito-larvicidal proteins in a gram-negative bacterium cpable of recolonization in the guts of Anopheles dirus larvae,” (Appl. Microbiol. Biotechnol. 51: 79-84, 1999).
McKillip et al. “Sporogenous midgut bacteria of the leafroller, Pandemis pyrusana (Lepidoptera: Tortricidae),” Environ. Entomol. 26 (6): 1475-1481, Dec. 1997.
Grace J. Kenneth
Husseneder Claudia
Oishi Darcy E.
Nixon & Peabody LLP
Priebe Scott D.
University of Hawai'i
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