Recombinant avirulent salmonella antifertility vaccines

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor

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4241841, 4242001, 4352523, 4352528, 435 693, 530395, C12N 121, A61K 4500

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active

056564880

ABSTRACT:
Avirulent microbes which include a recombinant expression system encoding a gamete-specific antigen, are disclosed. The microbes can be used in compositions to immunize a vertebrate subject against the gamete-specific antigen, thereby preventing or reducing conception rates in the subject to which they are administered.

REFERENCES:
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Curtiss, R. et al. Infect. Immun. 55(12):3035-3043. Dec. 1987, "Salmonella typhimurium Deletion Mutants . . . ".
Goldberg, E. et al. Fertility and Sterility 35(2):214-217. 1981. "Reduction of Fertility in Female Babboons . . . ".
W. F. Paul (ed), Fundamental Immunology, 3rd edition, pp. 1342-1344, Raven Press, New York (1993).

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