Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1997-11-14
2000-02-15
Mosher, Mary E.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
424 932, 435471, 4352523, 4352528, 435 4, 435 27, 435 29, A61K 3902, A61K 39112, A61K 39116, A61K 39295, C12N 121
Patent
active
060249617
ABSTRACT:
Avirulent immunogenic Salmonella enterica serotype Typhi and methods therefor are disclosed. The Salmonella have an RpoS.sup.+ phenotype, an inactivating mutation in one or more genes which renders the microbe avirulent, and a recombinant gene capable of expressing a desired protein. The Salmonella are avirulent and have high immunogenicity so that they can be used in vaccines and as delivery vehicles for the desired antigen. Also disclosed are methods for preparing the Salmonella and vaccine delivery vehicles therefor.
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Curtiss III Roy
Nickerson Cheryl A.
Mosher Mary E.
Washington University
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