Recombinant avipoxvirus

Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...

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4353201, 536 231, 935 32, C12N 701, C12N 1539, C12N 1586

Patent

active

053875192

ABSTRACT:
A recombinant Avipoxvirus having inserted exogenous DNA in a DNA region non-essential to proliferation of Avipoxvirus is provided. The recombinant Avipoxvirus is produced by inserting a promoter and exogenous DNA capable of expression under its control into a DNA region non-essential to proliferation of Avipoxvirus, utilizing DNA coding for a readily detectable enzyme, or, non-homologous DNA fragment.

REFERENCES:
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Chakrabarti et al., Mol. Cell. Biol., 5, 3403 (1985).
Mackett, M. et al. 1982, Proc. Natl. Acad. Sci. USA vol. 79 pp. 7415-7419.
Andrewes, C. et al. 1978, Viruses of Vertebrates, 4th edition, Bailliere Tindall, London p. 373.
Vieira & Messing Gene, 19 (1982) 259-268.
Boyle et al., J. Gen. Virol. 67, 1591 (1986).
Binns et al., Israel, J. Vet Med. 42, 124 (1986).
Panicali et al., Gene 47, 193 (1986).
Mackett et al., J. Gen. Virol 67, 2067 (1986).

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