Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2009-12-17
2010-10-05
Graser, Jennifer E (Department: 1645)
Chemistry: molecular biology and microbiology
Vector, per se
C536S023700, C424S239100
Reexamination Certificate
active
07807456
ABSTRACT:
The present invention discloses attenuatedClostridium perfringensorganisms that express a substantially nontoxic alpha-toxin. The expressed alpha-toxin is a deletion mutein that relative to the alpha-toxin of the mature alpha-toxin ofClostridium perfringensstrain 13, is missing at least nine consecutive amino acid residues including His68. The present invention also discloses attenuated organisms that encode the muteins, as well as the use of such attenuated organisms as vaccines.
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Cochran Mark D.
Lair Stephen V.
Petersen Gary R.
Synenki Richard M.
Graser Jennifer E
Intervet Inc.
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