Recombinant attenuated clostridium organisms and vaccine

Details Recombinant attenuated clostridium organisms and vaccine Recombinant attenuated clostridium organisms and vaccine

2007-04-12

2010-06-08

Graser, Jennifer E (Department: 1645)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

C435S243000, C435S252100, C424S247100, C424S200100, C424S235100

Reexamination Certificate

active

07732187

ABSTRACT:
The present invention discloses attenuatedClostridium perfringensorganisms that express a substantially nontoxic alpha-toxin. The expressed alpha-toxin is a deletion mutein that relative to the alpha-toxin of the mature alpha-toxin ofClostridium perfringensstrain 13, is missing at least nine consecutive amino acid residues including His68. The present invention also discloses attenuated organisms that encode the muteins, as well as the use of such attenuated organisms as vaccines.

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