Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant virus encoding one or more heterologous proteins...
Patent
1994-09-07
1998-06-16
Scheiner, Laurie
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant virus encoding one or more heterologous proteins...
4242081, 4242321, 4242011, 4353201, 435236, 4351723, A61K 3912, A61K 39295, A61K 3921, A61K 39275
Patent
active
057665982
ABSTRACT:
This invention is directed toward recombinant attenuated canarypox virus expression vectors containing exogenous DNA segments encoding lentiviral gene products. A parental canarypox virus (Rentschler strain) was obtained and attenuated through more than 200 serial passages on chick embryo fibroblasts. A master viral seed was subjected to four successive plaque purifications under agar and one plaque clone was amplified through five additional passages after which the stock virus was used as the parental virus in in vitro recombination studies. This attenuated plaque purified canarypox isolate was designated ALVAC. A series of ALVAC recombinants were generated that are capable of expressing different HIV and SIV gene products including Gag, Pol, Env, and Nef. These recombinants provide useful reagents for the generation of viral-specific immune responses.
REFERENCES:
patent: 5093258 (1992-03-01), Cohen
patent: 5174993 (1992-12-01), Paoletti
patent: 5180675 (1993-01-01), Prillien
patent: 5185146 (1993-02-01), Attenburger
Turner, P.C. et al. (90) Current topics in Microbiol. Immunol. 163: 125-151.
Lerner, R.A. et al. (83) in: The Biology of Immunologic Disease, eds. F.J. Dixon & D.W. Fisher, H.P. Publishing Co. New York, NY, pp. 331-338.
Wain-Hobson, S. et al. (85) Cell 40:9-17.
Cooney, E.L. et al. (91) Lancet 337:567-572.
Tartaglia, J. et al. (906) in: Immunochemistry of Viruses, eds. M.H.V. van Regenwortel and A.R. Newrath, Elsevier Science Publishers B.V. pp. 125-151.
Norley, S. et al. Immunobiology 184: 193-207 (1992).
Cohen, J. et al. Science 262: 980-81 (1993).
Moss, B., 1996, "Poxviridae: The Viruses and Their Replication"in Fields Virology, Third Edition, Fields et al., eds., Lippincott-Raven Publishers, Philadelphia, pp. 2637-2671.
Murphy, F., 1996, "Virus Taxonomy", in Fields Virology, Third Edition, Fields et al., eds., Lippincott-Raven Publishers, Philadelphia, pp. 15-57.
Taylor et al., 1991, Vaccine 9(3):190-193.
Berman et al., 1990, Nature 345:622-625.
Girard et al., 1991, Proc. Natl. Acad. Sci. USA 88:542-546.
Hu et al., 1986, Nature 320:537-540.
Ho et al., 1990, Eur. J. Immunol. 20:477-483.
Virology, vol. 173, No. 1, issued Nov. 1989, S. Dallo et al., "Humoral Immune Response Elicited by Highly Attenuated Variants of Vaccinia Virus and by an Attenuated Recombinant Expressing HIV-1 Envelope Protein", pp. 323-328 (entire document).
Virology, vol. 152, issued 1986, M.E. Perkus et al., "Insertion and Deletion Mutants of Vaccinia Virus", pp. 285-297 (entire document).
Nature, vol. 317, issued 31 Oct. 1985, R.M.L. Buller et al., "Decreased Virulence of Recombinant Vaccinia Virus Expression Vectors is Associated With a Thymidine Kinase-Negative Phenotype", pp. 813-815 (entire document).
Journal of Virology, vol. 62, No. 12, issued Dec. 1988, H. Shida et al., "Effects and Virulences of Recombinant Vaccinia Viruses Derived From Attenuated Strains That Express the Human T-Cell Leukemia Virus Type 1 Envelope Gene", pp. 4474-4480 (entire document).
Critical Reviews in Immunology, vol. 10, No. 1, issued 1990, J. Tartaglia et al., "Poxvirus-Based Vectors as Vaccine Candidates", pp. 13-30 (entire document). (Tartaglia 900).
Virology, vol. 188, No. 1, issued May 1992, J. Tartaglia et al., "NYVAC: A Highly Attenuated Strain of Vaccinia Virus", pp. 217-232 (entire document).
Hosmalin, A., Nara, P.L., Zweig, M., Lerche, N.W., Cease, K.B., Gard, E.A., Markham, P.D., Putney, S.D., Daniel, M.D., Desrosiers, R.C., and Berzofsky, J.A., J. Immunol. 146, 1667-1673 (1991).
Letvin, N.L., and King, N.W., J. AIDS 3, 1023-1040 (1990).
McMichael, A.J., Gotch, F.M., Noble, G.R., and Beare, P.A.S., New Engl. J. Med. 309, 13-17 (1983).
Moss, D.J., Rickinson, A.B., and Pope, J.H., Int. J. Cancer 22, 662-668 (1978).
Schmaljohn et al., Virology 155, 633-643 (1986).
Schmitt et al., J. Virol. 62, 1889-1897 (1988).
Tartaglia, J., Winslow, J., Goebel, S., Johnson, G.P., Taylor, J., and Paoletti, E., J. Gen. Virol. 71, 1517-1524 (1990).
Tartaglia et al., Virology 188, 217-232 (1992).
Taylor et al., Virology 187, 321-328 (1992).
Vos et al., EMBO J. 7, 3487-3492 (1988).
Walker, B.D. and Plata, F., AIDS 4, 177-184 (1990).
Walker, B.D., Chakrabarti, S., Moss, B., Paradi, T.J., Flynn, T., Durno, A.G., Blumberg, R.S., Kaplan, J.C., Hirsch, M.S., and Schooley, R.T., Nature 328, 345-348 (1987).
Walker, B.D., Flexner, C., Birch-Limberger, K., Fisher, L., Paradis, T.J., Aldovini, A., Young, R., Moss, B., and Schooley, R.T., Proc. Natl. Acad. Sci. 86, 9514-9519 (1989).
Weiss, R.A., Clapham, P.R., Cheingsong-Popov, R., Dalgleish, G., Carne, C.A., Weller, I.V., and Tedder, R.S., Nature 316, 69-72 (1985).
Yuen, L., and Moss, B., Proc. Natl. Acad. Sci. USA 84, 6417-6421 (1987).
Zagury, D., Bernard, J., Cheynier, R., Desportes, I., Leonard, R., Fouchard, I., Reveil, B., Ittele, D., Lurhuma, Z., Mbayo, K., Wane, J., Salaun, J.-J., Goussard, B., Dechazal, L., Burny, A., Nara, P. and Gallo, R.C., Nature 332, 728-731 (1988).
Zarling, J.M., Morton, W., Moran, P.A., McClure, J., Kosowski, S.G., and Hu, S.-L., Nature 323, 344-346 (1986).
Autran, B., Plata, F., and Debre, P., J. AIDS 4, 361-367 (1991).
Borysiewicz, I., Graham, S., Hickling, J., Mason, P.D., and Sissons, J.P.G., Eur. J. Immunology 18, 269-275 (1988).
Good, M.F., Maloy, W.L., Lunde, M.N., Margalit, H., Cornette, J.L., Smith, G.L., Moss, B., Miller, L.H., and Berzofsky, J.A., Science 235, 1059-1062 (1987).
Guo, P., Goebel, S., Davis, S., Perkus, M.E., Taylor, J., Norton, E., Allen, G., Lanquet, B., Desmettre, P., and Paoletti, E., J. virol. 174, 217-214 (1990).
Ho, P.C., Mutch, D.A., Winkel, K.D., Saul, A.J., Jones, G.L., Doran, T.J., and Rzepczyk, C.M., Eur. J. Immunol. 20, 477-483 (1990).
Ruegg, C.L., Monell, C.R., and Strand, M., J. Virol. 63, 3257-3260 (1989b).
Sanchez-Pascador, R., Power, M.D., Barr, P.J., Steimer, K.S., Stampien, M.M., Brown-Shimer, S.L., Gee, W., Renard, A., RAndolph, A., Levy, J.A., Dina, D., and Luciw, P.A., Science 227, 484-492 (1985).
Sanger, F., Nickeln, S., and Coulson, A. R., Proc. Natl. Acad. Sci. 74, 5463-5467 (1977).
Shaffermann, A., Lennox, J., Grosfeld, H., Sadoff, J., Redfield, R.R., and Burke, D.S., AIDS Research and Human Retroviruses 5, 33-39 (1989).
Shapira, S.K., Chou, J., Richaud, F.V., and Casadaban, M.J., Gene 25, 71-82 (1983).
Shioda, T. and H. Shibuta, Virology 175, 139-148 (1990).
Starcich et al., Cell 45, 637-648 (1986).
Tabor, S., and Richardson, C.C., Proc. Natl. Acad. Sci. USA 84, 4767-4771 (1987).
Tartaglia, J. and Paoletti, E., In Immunochemistry of viruses, II, eds. van Regenmortel, M.H.V and Neurath, A.R., (Elsevier Science Publishers B.V., Amsterdam) pp. 125 (1990).
Taylor, J. et al., Vaccine 6, 466-467 (1988).
Taylor, J. et al., Vaccine 9, 190-193 (1991).
Taylor, J., Weinberg, R., Lanquet, B., Desmettre, P., and Paoletti, E., Vaccine 6, 497-503 (1988a).
Taylor, J., Weinberg, R., Kawaoka, Y., Webster, R.G., and Paoletti, E., Vaccine 6, 504-508 (1988b).
Walker, B.D., Flexner, C., Paradis, T.J., Fuller, T.C., Hirsch, M.S., Schooley, R.T. and Moss, B., Science 240, 64-66 (1988).
Nixon, D.F., Townsend, A.R.M., Elvin, J.G., Rizza, C.R., Gallwey, J., and McMichael, A.J., Nature 326, 484-487 (1988).
Panicali, D., and Paoletti, E., Proc. Natl. Acad. Sci. USA 79, 4927-4931 (1982).
Perkus, M.E., Piccini, A., Lipinskas, B.R., and Paoletti, E., Science 229, 981-984 (1985).
Perkus, M.E., Goebel, S.J., Davis, S.W., Johnson, G.P., Limbach, K., Norton, E.K., and Paoletti, E., Virology 179, 276-286 (1990).
Perkus, M.E., Limbach K., and Paoletti, E., J. Virol. 63, 3829-3836 (1989).
Piccini, A., Perkus, M.E., and Paoletti, E., Methods in Enzymology 153, 545-563 (1987).
Plata, F., Autran, B., Martins, L.P., Wain-Hobson, S., Raphael, M., Mayaud, C., Denis, M., Guillon, J.-M., Debre, P., Nature 328, 348-351 (1987).
Ratner, L., Hasseltine, W., Patarca, R., Livak, K.J., Starcich, B., Josephs, S.F., Doran, E.R., Rafalski, J.A., Whitehorn, E.A., Baumeister, K., Ivanoff, L., Petteway, Jr., S.R., Pearson, M.L., Lautenberger, J.A., Papas, T.S., Ghrayeb, J., Chang, N.T., Gallo., R.C., and Wong-Staal F., Nature 313, 277-284 (1985).
Rautman
Cox William Irvin
Paoletti Enzo
Tartaglia James
Frommer William S.
Kowalski Thomas J.
Parkin Jeffrey S.
Scheiner Laurie
Virogenetics Corporation
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