Recombinant asparaginyl-tRNA synthetase from the human filarial

Details Recombinant asparaginyl-tRNA synthetase from the human filarial Recombinant asparaginyl-tRNA synthetase from the human filarial

1995-05-15

1996-10-01

Housel, James C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 4353201, 536 232, G12P 2106

Patent

active

055610544

ABSTRACT:
Recombinant asparaginyl tRNA synthetase from human filarial parasite Brugia malayi. The enzyme is used in an assay for inhibitors of the synthetase and can be used as an antigen for producing antibody inhibitors of the disease, either monoclonal or polyclonal. The antibodies can be used to detect the synthetase and related enzymes. In particular, the synthetase can be used to produce an antibody to be used for detecting filarial nematodes. The synthetase can be used to produce adenylated nucleosides.

REFERENCES:
McReynolds, L A et al, Southeast Asian J. Trop Med Public Health, 1993, pp. 55-63, Suppl. 2.
Gabuis, H J et al, Eur. J. Biohem, v 131, pp. 231-234, 1983.
Philipp, M., et al., Ann Rev. Microbiol. 42 685-716 (1988).
Carter, T. W., Ann. Rev. Biochem. 62 715-748 (1993).
EMBL Annual Report, 239-240 (1994).
Eriani, G., et al., Nature 347 203-206 (1990).
Cusack, S., et al., Nature 347 249-255 (1990).
Nilson, T. W., et al., Proc. Natl. Acad. Sci. USA 85 3604-3607 (1988).
Kron, M., et al., Mol. Biochem. Parasit. 52 289-292 (1992).
Cusack, S., et al., Nucleic Acids Research 19 3489-3497 (1991).
Targoff, I., et al., J. Clin. Invest. 91 2556-2564 (1993).
Love, L. A., et al., Medicine 70 360-374 (1991).
Bunn, C. C., et al., J. Exp. Med. 163 1281-1291 (1986).
Anselme, J., et al., Gene 84 481-485 (1989).
Bolle, P-A., et al., Yeast 8 205-213 (1992).
Bochner, B. R., et al., Cell, 37 225-232 (1984).
Segal, E., et al., Exp. Cell. Res. 167 119-126 (1986).
Walter, R. D., Trop. Med. Parasitol. 37 95 (1986).
Biou, V., et al., Science 263 1404-1410 (1994).
Belrhali, H., et al., Science 263 1432-1436 (1994).

Affiliated with

Also associated with

Rating

Recombinant asparaginyl-tRNA synthetase from the human filarial does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Recombinant asparaginyl-tRNA synthetase from the human filarial , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant asparaginyl-tRNA synthetase from the human filarial will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1501604