Recombinant antigen for diagnosing rheumatoid arthritis

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4352523, 43525233, 43525411, 4353201, 435325, 536 235, C12N 510, C12N 1512, C12N 1563, C12P 2102

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057233144

ABSTRACT:
A method is described for diagnosing rheumatoid arthritis by providing a recombinant antigen (RAMA) and detecting rheumatoid arthritis-associated IgM antibodies against the RAMA antigen in patient sera. The RAMA antigen comprises SEQ ID NO:3 and peptides substantially homologous thereto. A purified and isolated DNA encoding the RAMA antigen and a transformed host containing the DNA are also disclosed.

REFERENCES:
patent: 5395753 (1995-03-01), Prakash
J. Lawrence Burg et al., Molecular analysis of the gene encoding the major surface antigen of Toxoplasma gondii, 141 Journal of Immunology 3584-3591 (1988).
M.F. Cesbron-Delauw et al., Molecular characterization of a 23-kilodalton major antigen secreted by Toxoplasma gondii, 86 Proc. Natl. Acad. Sci. USA 7537-7541 (1989).
W.J.A. Habets et al., Detection of autoantibodies in a quantitative immunoassay using recombinant ribonucleoprotein antigens, 76 Clin. exp. Immunol. 172-177 (1989).
Frank R. Jirik et al, Cloning and sequence determination of a human rheumatoid factor light-chain gene, 83 Proc. Natl. Acad. Sci. USA 2195-2199 (1986).
J. Kemp et al., Analysis of rheumatoid factors by a biotin-avidin based isotype-specific ELISA, 93(5) Acta Pathol Microbiol Immunol Scand Sect C Immunol 217-224 (1985), Biol. Abstr. 81(7):63056 (1986).
Mongkol Kunakorn et al., Enzyme-Linked Immunosorbent Assay for Immunoglobulin M Specific Antibody for the Diagnosis of Melioidosis, 28 Journal of Clinical Microbiology 1249-1253 (1990).
"A. Extraction and Isolation of Eukaryotic Messenger RNA (mRNA)", Recombinant DNA Methodology, 83-88 (1985).
Seymour P. Halbert, M.D., Jacob Karsh, M.D., and Milton Anken, M.A., A Quantitative Enzyme Immunoassay for IgM Rheumatoid Factor Using Human Immunoglobulin G as Substrate, 74 Am. J. Clin. Pathol. 776-784 (1980).
Steven E. Artandi et al., Molecular Analysis of IgM Rheumatoid Factor Binding to Chimeric IgG, 146 Journal of Immunology 603-610 (1991).
Rosemary O. Shade et al., Nucleotide Sequence and Genome Organization of Human Parvovirus B19 Isolated from the Serum of a Child during Aplastic Crisis, 58 Journal of Virology 921-936 (1986).

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