Recombinant antigen for diagnosing rheumatoid arthritis

Details Recombinant antigen for diagnosing rheumatoid arthritis Recombinant antigen for diagnosing rheumatoid arthritis

1994-12-27

1996-12-17

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435 71, 436547, C07K 14435, G01N 3353

Patent

active

055854648

ABSTRACT:
A method is described for diagnosing rheumatoid arthritis by providing a recombinant antigen (RAMA) and detecting rheumatoid arthritis-associated IgM antibodies against the RAMA antigen in patient sera. The RAMA antigen comprises SEQ ID NO:3 and peptides substantially homologous thereto. A purified and isolated DNA encoding the RAMA antigen and a transformed host containing the DNA are also disclosed.

REFERENCES:
Burg et al., J. Immunol. 141:3584-3591 (1988).

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