Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Patent
1994-07-27
1997-07-22
Feisee, Lila
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
4241331, 424 851, 435 697, A61K 39395, A61K 3940, A61K 4505, C12P 2104
Patent
active
056501501
ABSTRACT:
Immunoconjugates for the selective delivery of a cytokine to a target cell are disclosed. The fusion proteins are comprised of an immunoglobulin heavy chain having a specificity for the target cell, such as a cancer or virus-infected cell, and a cytokine, such as lymphotoxin, tumor necrosis factor alpha, interleukin-2, or granulocyte-macrophage colony stimulating factor, joined via its amino terminal amino acid to the carboxy-terminus of the immunoglobulin. Nucleic acid sequences encoding these fusion proteins and methods of their preparation by genetic engineering techniques are also disclosed.
REFERENCES:
patent: 4196265 (1980-04-01), Koprowski et al.
patent: 4469797 (1984-09-01), Albarella
patent: 4676980 (1987-06-01), Segal et al.
patent: 4946778 (1990-08-01), Ladner et al.
patent: 5073627 (1991-12-01), Curtis et al.
patent: 5114711 (1992-05-01), Bell et al.
patent: 5314995 (1994-05-01), Fell et al.
Neerberger et al. "Nature" vol. 312 p. 604 1984.
Harris et al. Trends Biotechnol. vol. 11 p. 42, 1993.
Karpovsky et al. (1984) J. Experimental Medicine 160:1686-1701.
Kranz et al. (1984) Proc. Natl. Acad. Sci. USA 81:7922-7926.
Henkart (1985) Ann. Rev. Immunol 3:31-58.
Liu et al. (1985) Proc. Natl. Acad. Sci. USA 82:8648-8652.
Jung et al. (1986) Proc. Natl. Acad. Sci. USA 83:4479-4483.
Murphy et al. (1986) Proc. Natl. Acad. Sci. USA 83:8258-8262.
Perez et al. (1986) J. Experimental Medicine 163:166-178.
Santon et al. (1986) Cancer Research 46:4701-4705.
Shen et al. (1986) J. Immunology 137:3378-3382, No. 11.
Williams et al. (1987) Protein Engineering 1:493-498, No. 6.
Bacha et al. (1988) J. Experimental Medicine 167:612-622.
Chaudhary et al. (1988) Nature 335:369-372.
Liu et al. (1988) Science 239:395-398.
Till et al. (1988) Science 242:1166-1168.
Capon et al. (1989) Nature 337:525-530.
Pastan et al. (1989) J. Bio.Chem. 264:15157-15160, No. 26.
Gillies et al. (1989) J. Immuno. Methods 125:191-202.
Gillies et al. (1989) Bio/Technology 7:799-804.
Shin et al. (1990) Proc. Natl. Acad. Sci. USA 87:5322-5326.
Taniguchi et al. (1983) Macmillan Journals Ltd. "Structure and expression of a cloned cDNA for human interleukin-2".
Gasson et al. (1984) Science 226:1339-1342.
Nedwin et al. (1985) Nucleic Acids Res. 13:6361-6373.
Goeddel et al. (1986) "Tumor Necrosis Factors: Gene Structure and Biological Activities" pp. 597-609.
Beutler et al. (1988) Ann. Rev. Biochem. 57:505-518.
Paul et al. (1988) Ann. Rev. Immunol. 6:407-438.
Gillies et al. (1990) Hum. Antibod. Hybridomas 1:47-54.
Williams et al. (Abstract).
Biosis Abstract No. 91:367080, Biol. Abstr. 92:55305 and Biochim. and Biophys. Acta 1096:345-354 (1991).
Herrmann et al. (1989) J. Clin. Oncol. 7(2):159-167; "Hematopoeitic Responses With Advanced Malignancy Treated With Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor".
Ebert Ray F.
Feisee Lila
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