Recombinant antibody

Details Recombinant antibody Recombinant antibody

1994-08-18

1997-10-14

Ziska, Suzanne E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530350, 5303873, 5303911, 5303913, 530866, 530867, 4351723, C12N 1500, C07K 1400, C07K 1600, C12P 2108

Patent

active

056774257

ABSTRACT:
The present invention provides an altered antibody molecule (AAM) having a hinge region which has a different number of cysteine residues from that found in the hinge region normally associated with the CH1 domain of the antibody molecule and a process for producing the same using recombinant DNA technology.

REFERENCES:
patent: 4751077 (1988-06-01), Bell
patent: 4816567 (1989-03-01), Cabilly et al.
Oi et al Nature 307: 136,1984.
Morrison, Science 229: 1202,1985.
Oi et al., "Correlation Between Segmental Flexibility and Effector Function of Antibodies" Nature 307: 136-140 (1984).
Morrison, "Transfectomas Provide Novel Chimeric Antibodies" Science 229: 1202-1207 (1985).
Krawinkel and Rabbitts, "Comparison of the Hinge-Coding Segments in Human Immunoglobulin Gamma Heavy Chain Genes and the Linkage of the Gamma 2 and Gamma 4 Subclass Genes", Embo Journal 1: 403-407 (1982).
Krawenhel et al EMBO J 1:403,1982.
Stites in Basic & Clinical Immunology, 1984, pp. 30-42.
WO, A, 86/01533 (Celltech) 13 Mar. 1986 )cited in the application).

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