Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-06-07
2000-04-25
Campell, Bruce R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
4353201, C07H 2102, C12N 1563
Patent
active
060545666
ABSTRACT:
The present invention relates to a recombinant viral nucleic acid selected from a (+) sense, single stranded RNA virus possessing a native subgenomic promoter encoding for a first viral subgenomic promoter, a nucleic acid sequence that codes for a viral coat protein whose transcription is regulated by the first viral subgenomic promoter, a second viral subgenomic promoter and a second nucleic acid sequence whose transcription is regulated by the second viral subgenomic promoter. The first and second viral subgenomic promoters of the recombinant viral nucleic acid do not have homologous sequences relative to each other. The recombinant viral nucleic acid provides the particular adivantage that it systemically transcribes the second nucleic acid in the host. Host organisms encompassed by the present invention include procaryotes and eucaryotes, particularly animals and plants.
The present invention also relates to viruses containing the viral vectors which are infective, production cells which are capable of producing the viruses or parts thereof, a host infected by the viruses of the invention, the gene products produced by expression of the viral nucleic acids and a process for the production of a desired product by growing the infected hosts.
REFERENCES:
patent: 4348477 (1982-09-01), Nakano et al.
patent: 4508826 (1985-04-01), Foor et al.
patent: 4593002 (1986-06-01), Dulbecco
patent: 4603112 (1986-07-01), Paoletti et al.
patent: 4698307 (1987-10-01), Mabe et al.
patent: 4797368 (1989-01-01), Carter et al.
patent: 4808537 (1989-02-01), Stroman et al.
patent: 4855237 (1989-08-01), Morinaga et al.
patent: 4873316 (1989-10-01), Meade et al.
patent: 4898414 (1990-02-01), Kwon
patent: 5128460 (1992-07-01), Piatak, Jr. et al.
patent: 5316931 (1994-05-01), Donson et al.
Orkin et al., 1995, "Report and Recommndations of the Panel to assess the NIH investment in Research on Gene Therapy", National Institutes of Health, Dec. 1995.
Webster's New Riverside Dictionary II, 1994 page "synonymist-sysienie".
Berger et al (1987). Guide to Molecular Cloning Techniques p.20-21.
Hahn et al (1992). Proc. Natl. Acad. Sci USA 89, 2679-83.
Donson et al (1991). Proc. Natl. Acad. Sci USA 88, 7204-08.
Bujarski et al (1986). Nature 321, 528-531.
Lewin (1987) Science 237, 1570.
Reeck et al (1987). Cell 50, 667.
Hahn et al., 1992, "Infectious Siindbis virus transient expression vectors for studying antigen processing and presentation," Proc. Natl. Acad. Sci. U.S.A. 89:2679-2683.
1979, 1983, 1983, 1986, 1987, "Methods in Enzymology," vols. 68, 100, 101, 118, 152, 153, 154, 155.
Abel et al., 1986, Science 232:738.
Adams et al., 1976, J. Pharm Pharmac 28:256.
Ahlquist, et al., 1981, "Complete Nucleotide Sequence of Brome Mosaic Virus RNA3," J. Mol. Biol. 153: 23-28.
Ahlquist and Janda, 1984, "cDNA Cloning and In Vitro Transcription of the Complete Brome Mosaic Virus Genome," Mol. and Cell. Biol. 4:2876-2882.
Ahlquist and French, 1984, "Multicomponent RNA Plant Virus Infection Derived from Clones Viral cDNA," Proc. Natl. Acad. Sci. USA 81: 7066-7070.
Ahlquist et al., 1990, Virology 172:285-292.
Ahlquist et al., 1990, Physiologia Plantarium 79:163-167.
Alan R. Liss Inc., 1989, "Pollen-specific expression directed by chimaeric genes in transgenic tomato and tobacco plants," J. Cell. Bio. Suppl. 13D:312.
Alan R. Liss, Inc., 1989, "Plant transformation as a test of the relationship between cytoplasmic male sterility, respiratory phenotype, and the PCF gene," J. Cell. Bio. Suppl. 13D:299.
Ausubel et al., 1987, Current Protocols in Mol. Biol., Wiley, New York.
Beck, et al., 1982, "Nucleotide Sequence and Exact Localization of the Neomycin Phosphotransferase Gene from Transposon Tn5," Gene 19:327-336.
Bernan et al., 1985, Gene 37:101.
Bernard, et al., 1979, "Construction of Plasmid Cloning Vehicles that Promote Gene Expression From the Bacteriophage Lambda .rho..sub.L Promoter," Gene 5: 59-76.
Bishop, 1991, "Tobacco Plants Become Assembly Lines for Scientists Producing New Chemicals," The Wall Street J.
Bradford, Marion 1976, "A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding," Anal. Biochem. 72: 248-254.
Brindle et al., 1990, "Multiple Factors Bind the Upstream Activation Sites of the Yeast Enolase Genes ENO1 and ENO2: ABFI Protein, like Repressor Activator Protein RAP1, Binds cis-Acting Sequences Which Modulate Repression or Activation Transcription," Mol. and Cell. Biol. 10:4872-4885.
Brinton et al., (eds.) Am. Soc. Microbial Publisher pp. 3-11.
Brisson, et al., 1984, "Expression of a Bacterial Gene in Plants by Using a Viral Vector," Nature 310: 511-514.
Brisson and Hohn, 1986, "Plant virus Vectors: Cauliflower Mosaic Virus," Methods in Enzymology 118: 659-668.
Buchman et al., 1988, "Two DNA-Binding Factors Recognize Specific Sequences at Silencers, Upstream Activating Sequences, Autonomously Replicating Sequences, and Telomeres in Saccharomyces cerevisiae", Mol. and Cell. Biol. 8:210-225.
Bujarski and Kaesberg, 1986, "Genetic Recombination between RNA Components of a Multipartite Plant Virus," Nature 321: 528-531.
Buttioni et al., 1983, J. Pharm. Pharmac 35:603.
Chow, et al., "Isolation and DNA Sequence of a Gene Encoding ( )-Trichosanthin, a Type I Ribosome-inactivating Protein," J. Biol. chem. 265: 8670-8674 (1990).
Clare et al., 1991, "High-Level Expression of Tetanus Toxin Fragment C in Pichia Pastoris Strains Containing Multiple Tandem Integrations of the Gene," Bio/Technology 9:455-460.
Clover, D.M., 1985, "Molecular Cloning," IRL Press, Oxford.
Cohen et al., 1987, "Transcription of the Constitutively Expressed Yeast Enolase Gene ENO1 Is Mediated by Positive and Negative cis-Acting Regulatory Sequences," Mol. and Cell. Biol. 7:2753-2761.
Collins, et al., 1990, "Primary Amino Acid Sequence of .alpha.-Trichosanthin and Molecular Models for Abrin A-chain and .alpha.-Trichosanthin," J. Biol. Chem. 265: 8665-8669.
Connett et al., 1989, "Plant transformation as a test of the relationship between cytoplasmic male sterility, respiratory phenotype, and the PCF gene," J. Cell. Biochem. Suppl. 13D abstract M310:299.
Cregg et al., 1987, "Functional Characterization of the Two Alcohol Oxidase Genes from the Yeast Pichia pastoris," Mol. and Cell. Biol. 9:1316-1323.
Cregg et al., 1987, "High-Level Expression and Efficient Assembly of Hepatitis B Surface Antigen in The Methylotohic Yeast, Pichia Pastoris," Bio/Technology 5:479-485.
Cuzzo et al., 1988, Bio/tech 6:549.
Dawson et al., 1986, "cDNA Cloning of the Complete Genome of Tobacco Mosaic Virus and Production of Infectious Transcripts," Proc. Natl. Acad. Sci. U.S.A. 83: 1832-1836.
Dawson, et al., 1988, "Modifications of the Tobacco Mosaic Virus coat Protein Gene Affecting Replication, Movement, and Symptomatology," Phytopathology 78: 783-789.
Dawson et al., 1989, "A Tobacco Mosaic Virus-Hybrid Expresses and Loses an Added Gene," Virology 172:285-292.
Deom et al., 1987, "The 30-Kilodalton Gene Product of Tobacco Mosaic Virus Potentiates Virus Movement," Science 237: 389-394.
Dewey, et al., 1986 "Novel Recombinations in the Maize Mitochondrial Genome Produce a Unique Transcriptional Unit in the Texas Male-Sterile Cytoplasm," Cell 44: 439-449.
Donson, et al., 1988, "Agrobacterium-Mediated Infectivity of Cloned Digitaria Streak Virus DNA," Virology 162: 248-250.
Donson, et al., 1991, "Systematic Expression of a Bacterial Gene by a Tobacco Mosaic Virus-based Vector," Proc. Natl. Acad. Sci. USA 88: 7204-7208.
Dougherty, William, 1983, "Analysis of Viral RNA Isolated from Tobacco Leaf Tissue Infected with Tobacco Etch Virus," Virology 131: 473-481.
Dougherty et al., 1986, Virol 149:107.
Ebert, et al., 1989, "Gentic Polymorphism of Self-Incompatibility in Flowering Plants," Cell 56: 255-262.
Ellis et al., 1985, "Isolation of alcohol Oxidase and Two Other Methanol Regulateable Genes from the Yeast Pichia pastoris," Mol. and Cell. Biol. 5:1111-1121.
Elmer, et al., 1988, "Agrobacterium-Mediated Inoculation of Plants with Tomato Golden Mosaic Virus DNA's," Plant Molecular Biology 10: 225-234.
Endo,
Dawson William O.
Donson Jon
Garger Stephen J.
Granthan George L.
Grill Laurence K.
Bendrick John A.
Biosource Technologies, Inc.
Campell Bruce R.
Clark Deborah J. R.
Halluin Albert P.
LandOfFree
Recombinant animal viral nucleic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Recombinant animal viral nucleic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant animal viral nucleic acids will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-994310