Recombinant and chimeric KS1/4 antibodies directed against a hum

Details Recombinant and chimeric KS1/4 antibodies directed against a hum Recombinant and chimeric KS1/4 antibodies directed against a hum

1988-04-21

1990-12-04

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

536 27, 435320, 4351723, 4352401, 935 70, 935 71, 935 41, 530387, C12N 510, C12N 100, C12N 1500

Patent

active

049753690

ABSTRACT:
The present invention comprises novel recombinant DNA compounds which encode monoclonal antibody KS1/4 and chimeric derivatives of monoclonal antibody KS1/4. Eukaryotic expression vectors have been constructed that comprise novel KS1/4-encoding DNA and drive expression of KS1/4 when transformed into an appropriate host cell. The novel expression vectors can be used to create modified and chimeric derivatives of KS1/4. The recombinant-produced KS1/4, KS1/4 derivatives and KS1/4 chimeras are useful for the diagnosis, prognosis and treatment of disease states including adenocarcinoma.

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