Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1998-02-18
2000-07-25
Minnifield, Nita
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530350, 530829, 514 12, 514 21, 514 2, 435 691, 435 693, 435 71, 424 88, 424 92, 424534, C07K 1400, C07K 14435, A61K 3803, A61K 3817
Patent
active
060938013
ABSTRACT:
The present invention provides a composition comprising a BPI Protein and an anionic compound which composition exhibits (1) no bacterial activity and (2) endotoxin neutralizing activity. Also, this invention provides methods for using BPI Proteins.
REFERENCES:
patent: 5234912 (1993-08-01), Scott et al.
patent: 5308834 (1994-05-01), Scott et al.
patent: 5334584 (1994-08-01), Scott et al.
patent: 5770694 (1998-06-01), Scott et al.
Marra et al., "Bactericidal/Permeability-Increasing Protein Has Endotoxin-Neutralizing Activity" J. Immunol. (1990) 144:662-666.
Elsbach et al., "Bactericidal/Permeability Increasing Protein (BPI) of Granulocytes: Structure and Function" Bacteria-Host Cell Interaction (1988) pp. 47-60.
Gray et al., "Cloning of the Gene of the Human Bactericidal/Permeability Increasing Protein and Identification of Structure-Function Relationships" Clinical Research (1988) 36(3):620A.
Gray et al., "Cloning of the cDNA of a Human Neutrophil Bactericidal Protein" J. Biol. Chem. (1989) 264(16):9505-9509.
Weiss et al., "Killing of Gram-Negative Bacteria by Polymorphonuclear Leukocytes" The American Society of Clinical Investigation, Inc. (1982) 69:959-970.
Weiss et al., "Oxygen-independent intracellular and Oxygen-dependent Extracellular Killing of Escherichia coli S15 by Human Polymorphonuclear Leukocytes" The American Society of Clinical Investigation, Inc. (1985) 76:206-212.
Leong et al., "Cloning of the cDNA of a Human Neutrophil Bactericidal Protein" J. Cell Biochem. Suppl. (1989) 13:66.
Weiss et al., "Sensitivity of K1-Encapsulated Escherichia coli to Killing by the Bactericidal/Permeability-Increasing Protein of Rabbit and Human Neutrophils" Infection and Immunity (1982) 38:1149-1153.
Muello et al., "The Role of Endotoxin in the Action of the Bactericidal/Permeability Increasing Neutrophil Protein on the Bacterial Envelope" Clinical Research (1983) 31(2):371A.
Weiss et al., "Role of Charge and Hydrophobic Interactions in the Action of the Bactericidal/Permeability-increasing Protein of Neutrophils on Gram-negative Bacteria" J. Clin. Invest. (1983) 71:540-549.
Shafer et al., "Cationic Antimicrobial Proteins Isolated from Human Neutrophil Granulocytes in the Presence of Diisopropyl Fluorophosphate" Infection and Immunity (1984) 45:29-35.
Hovde et al., "Characterization of a Protein from Normal Human Polymorphonuclear Leukocytes with Bactericidal Activity against Pseudomonas aeruginosa" Infection and Immunity (1986) 54(1):142-148.
Weiss et al., "Environmental Modulation of Lipopolysaccharide Chain Length Alters the Sensitivity of Escherichia coli to the Neutrophil Bactericidal/Permeability-Increasing Protein" Infection and Immunity (1986) 51(2):594-599.
Spitznagel et al., "A Monoclonal Antibody that Inhibits the Antimicrobial Action of a 57 KD Cationic Protein of Human Polymorphonuclear Leukocytes" J. Immunol. (1987) 139(4):1291-1296.
Farley et al., "Antimicrobial Binding of a Radiolabeled Cationic Neutrophil Granule Protein" Infection and Immunity (1987) 55(6):1536-1539.
Veld et al., "Effects of the Bactericidal/Permeability-Increasing Protein of Polymorphonuclear Leukocytes on Isolated Bacterial Cytoplasmic Membrane Vesicles" Infection and Immunity (1988) 56(5):1203-1208.
Farley et al., "Lipopolysaccharide Structure Determines Ionic and Hydrophobic Binding of a Cationic Antimicrobial Neutrophil Granule Protein" Infection and Immunity (1988) 56(6):1589-1592.
Mannion et al., "Preferential Binding of the Neutrophil Cytoplasmic Granule-Derived Bactericidal/Permeability Increasing Protein to Target Bacteria" J. Immunol. (1989) 142(8):2807-2812.
Weiss et al., "The Bactericidal/Permeability-Increasing Protein of Neutrophils Retains its Biological Activities After Cleavage by Neutrophil Proteases" ASCI Metabolism (1985) 33(2):567A.
Mannion et al., "Separation of Sublethal and Lethal Effects of the Bactericidal/Permeability Increasing Protein on Escherichia coli" J. Clin. Invest. (1990) 85:853-860.
Pereira et al., "The Ontogeny of a 57-Kd Cationic Antimicrobial Protein of Human Polymorphonuclear Leukocytes: Localization to a Novel Granule Population" Blood (1990) 76(4):825-834.
Schumann et al., "Structure and Function of Lipopolysaccharide Binding Protein" Science (1990) 249:1429-1431.
Larrick et al., "Complementary DNA sequence of rabbit CAP18--a unique lipopolysaccharide binding protein" Biochem. Biophys. Res. Commun. (1991) 179(1):170-175.
Cross et al., "Choice of Bacteria in Animal Models of Sepsis" Infection and Immunity (1993) 61(7):2741-2747.
Ooi et al., "A 25-kDa NH.sub.2 -terminal Fragment Carries All the Antibacterial Activities of the Human Neutrophil 60-kDa Bactericidal/Permeability-increasing Protein" J. Biol. Chem. (1987) 262(31):14891-14894.
Tobias et al., "A Family of Lipopolysaccharide Binding Proteins Involved in Responses to Gram-negative Sepsis" J. Biol. Chem. (1988) 263(27):13479-13481.
Ooi et al., "Endotoxin-neutralizing Properties of the 25 kD N-Terminal Fragment and a Newly Isolated 30 kD C-Terminal Fragment of the 55-60 kD Bactericidal/Permeability-increasing Protein of Human Neutrophils" J. Exp. Med. (1991) 174:649-655.
Geisow, "Glycoprotein glycans--roles and controls" Tibech (1992) 10:333-335.
Bowie et al, Deciphering the message in protein sequences:Tolerance to amino acid substitution. Science, vol. 247, p1306-1310, 1990.
Houghten et al, Relative importance of position and individual amino acid residues in peptide antigen-antibody interactions:Implications in the mechanism of antigenic drift and antigenic shift. Vaccines 86, pp2125, 1986.
Pereira et al. The ontogeny of a 57-Kd cationic antimicrobial protein of human polyphonuclear leukocytes:Localization to a novel granule population., Blood vol., 76, pp 825-834, 1990.
Hovde et al , Characterization of a protein from normal human polymorphonuclear leukocytes with bactericidal activity against Pseudomonas aeruginosa, Infection and immunity, von 54, pp142-148, 1986.
Ooi et al, A 25 -Kda NH2-terminal fragment carries all the antibacterial activities of the human neutrophil 60-kDa bactericidal/permeability-increasing protein, J.Biological Chemistry, vol. 262, pp14891-14894, 1987.
Marra Marian N.
Scott Randal W.
Baskar Padma
Incyte Pharmaceuticals Inc.
Minnifield Nita
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