Recombinant Alzheimer's protease inhibitory amyloid protein and

Details Recombinant Alzheimer's protease inhibitory amyloid protein and Recombinant Alzheimer's protease inhibitory amyloid protein and

1989-06-06

1993-06-29

Hill, Jr., Robert J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, 530839, 530350, 435 692, A61K 3764, C07K 710

Patent

active

052234827

ABSTRACT:
DNA sequences encoding .beta.-amyloid-related proteins associated with Alzheimer's disease are disclosed. Also provided herein is a DNA sequence encoding a novel protease inhibitor. These sequences are used in producing or constructing recombinant .beta.-amyloid core protein, .beta.-amyloid-related proteins and recombinant or synthetic immunogenic peptides. Antibodies generated against the recombinant proteins or immunogenic peptides derived therefrom can be used for cerebral fluid or serum protein diagnosis of Alzheimer's disease.

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