Recombinant alveolar surfactant protein

Details Recombinant alveolar surfactant protein Recombinant alveolar surfactant protein

1993-06-09

1995-07-04

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, 530350, 435 691, C07K 700, C07K 1506

Patent

active

054300207

ABSTRACT:
The complete coding sequences and amino acid sequences for both canine and human 32K alveolar surfactant proteins (ASP) are disclosed; clones encoding variants of the SP-18 and SP-5 forms of human protein are disclosed. Methods and vectors for obtaining these proteins in recombinant form are also described. An improved method for purification of the 32K protein takes advantage of its carbohydrate affinity. Pharmaceutical compositions in the treatment of respiratory deficiency syndrome use the 10K proteins with or without the 32K form. Synthetic peptides based on the human SP-5 protein are provided as well, which peptides show significant ASP activity.

REFERENCES:
patent: 4603124 (1986-07-01), Takei et al.
patent: 4659805 (1987-04-01), Schilling, Jr. et al.
patent: 4861756 (1989-08-01), Jackson
patent: 4882422 (1989-11-01), Taeusch et al.
patent: 4912038 (1990-03-01), Schilling
patent: 4918161 (1990-04-01), Stanbrink et al.
patent: 5055553 (1991-10-01), Jacobs et al.
Olafson, R. et al., Biochem. Biophys. Res. Commun.148(3):1406-1411, Nov. 13, 1987.
Glasser, S. et al., PNAS, 84:4007-4011, Jun. 1987.
Hawgood, S., et al., PNAS, 84:66-70, Jan. 1987.
Jacobs, K. et al., J. of Biol. Chem., issue of Jul. 15, 1987, pp. 9808-9811.
Whitsett, J. et al., Pediatric Research, 20(8):744-749, 1986.
Whitsett, J. et al., Pediatric Research, 20(5):460-467, 1986.

Affiliated with

Also associated with

Rating

Recombinant alveolar surfactant protein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Recombinant alveolar surfactant protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant alveolar surfactant protein will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-760184