Recombinant altered antibodies and methods of making altered ant

Details Recombinant altered antibodies and methods of making altered ant Recombinant altered antibodies and methods of making altered ant

1991-10-25

1993-07-06

Lacey, David L.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

424 858, 424 8591, 435 696, 435 7021, 4351722, 4351723, 43524027, 4352523, 43525233, 4353201, 935100, 935104, 935107, C07K 1528, A61K 39395, C12N 512, C12N 1513

Patent

active

052255395

ABSTRACT:
An altered antibody is produced by replacing the complementarity determining regions (CDRs) of a variable region of an immunoglobulin (Ig) with the CDRs from an Ig of different specificity, using recombinant DNA techniques. The gene coding sequences for producing the altered antibody may be produced by site-directed mutagenesis using long oligonucleotides.

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