Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-06-14
1998-07-14
Campbell, Bruce R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
424 932, 424 9321, 4351723, 4353201, 435325, 435375, 935 22, 935 34, 935 62, A01N 6300, A61K 4800, C12N 500, C12N 1500
Patent
active
057804478
ABSTRACT:
The present invention provides a vector comprising an enhancer element and a nuclear matrix association region inserted between an inverted terminal repeat of adeno-associated virus. The vector can further comprise a heterologous nucleic acid inserted into the vector. The present invention further provides a method for integration of a nucleic acid into the genome of a cell, comprising administering to the cell a vector comprising an enhancer element, a heterologous nucleic acid and a nuclear matrix association region, each inserted between an inverted terminal repeat of adeno-associated virus, thereby integrating the nucleic acid into the genome of the cell.
REFERENCES:
patent: 5252479 (1993-10-01), Srivastava
E. Marshall (1995) Science 269: 1050-1055.
Ville et al. (1995) Targeted Gene Therapy 9: 190-199.
Li and Stamatoyannopoulos, "Position Independence and Proper Developmental Control of .gamma.-Globin Gene Expression Require both a 5' Locus Control Region and a Downstream Sequence Element", Mol. Cell. Biol. 14:6087-6096 (1994).
Walsh et al., "Regulated high level expression of a human .gamma.-globin gene introduced into erythroid cells by an adeno-associated virus vector", Proc. Natl. Acad. Sci. USA 89: 7257-7261 (1992).
Miller et al., "Recombinant adeno-associated virus (AAV)-mediated expression of a human .gamma.-globin gene in human progenitor-derived erythroid cells", Proc. Natl. Acad. Sci. USA 91: 10183-10187 (1994).
Cunningham et al., "The Regulatory Element 3' to the .sup.A .gamma.-Globin Gene Binds to the Nuclear Matrix and Interacts With Special A-T-Rich Binding Protein 1 (SATB1), an SAR/MAR-Associating Region DNA Binding Protein", Blood 84: 1298-1308 (1994).
Bodine and Ley, "An enhancer element lies 3' to the human A.gamma. globin gene", EMBO J. 6: 2997-3004 (1987).
Walsh et al., "Gene Therapy for Human Hemoglobinopathies", P.S.E.B.M. 204: 289-300 (1993).
Goodman et al., "Recombinant Adeno-Associated Virus-Mediated Gene Transfer Into Hematopoietic Progenitor Cells", Blood 84: 1492-1500.
Campbell Bruce R.
St. Jude Children's Research Hospital
LandOfFree
Recombinant adeno-associated viral vectors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Recombinant adeno-associated viral vectors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant adeno-associated viral vectors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1881833