Recombinant 40 KDa Dermatophagoides farinae allergen

Details Recombinant 40 KDa Dermatophagoides farinae allergen Recombinant 40 KDa Dermatophagoides farinae allergen

1991-08-22

1994-05-24

Nucker, Christine M.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530858, 530403, 424 88, 424 91, 435 693, 435 71, 435 697, 4351721, 536 234, 536 235, C07K 1508, C07K 1500, C07K 1512

Patent

active

053149912

ABSTRACT:
The present invention is directed to a recombinant mite allergen obtainable by expression of a mite-body-derived gene, a gene which codes for said allergen, a mite allergen fragment, a polypeptide having an epitope contained in said allergen, an expression vector capable of expressing the gene, a bacterium, yeast or mammalian cell transformed with said expression vector, a method for producing said allergen, and a pharmaceutical composition or a diagnostic reagent for the treatment of mite allergic diseases.

REFERENCES:
Heymann, P. W. et al. (86) J. Immunol. 137: 2841-2847.
Young, R. A. et al (83) Proc. Natl. Acad. Sci USA 80: 1194-1198.
Uhlen, M. et al (90) Methods in Enzymology, 185: 129-143.
Chua et al, Int. Arch. Allergy Immunol 1990:91: 1:118-123.
Chua et al, Int. Arch. Allergy Appl. Immunol 1990:91:124-129.
Thomas et al, Int. Archs Allergy appl. Immun. 85 127-129 (1988).
Yuuki et al, Agric. Biol. Chem., 55 (5) 1233-1238, 1991.
Tovey et al, J. Exp. Med. vol. 170, Oct. 1989 1457-1462.
Chua et al, J. Exp. Med. vol. 167, Jan. 1988 pp. 175-182.
Yuuki et al, Jpn. J. Allergol, 39, (6), 557-561, 1990.

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