Recombinant 3-des-OH-cystatin C produced by expression in a proc

Details Recombinant 3-des-OH-cystatin C produced by expression in a proc Recombinant 3-des-OH-cystatin C produced by expression in a proc

1992-08-13

1995-07-11

Draper, Garnette D.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435 692, C12N 1570, C12N 1574, C07K 1481

Patent

active

054322642

ABSTRACT:
A recombinant cystatin C polypeptide or a derivative thereof, such as 3-des-hydroxy-cystatin C, is produced biosynthetically by fermentation of a microorganism into which plasmids containing a DNA-sequence coding for said polypeptide have been introduced. Preparations containing recombinant cystatin C, preferably 3-des-hydroxy-cystatin C, have a higher cystein proteinase inhibitor activity than native cystatin C, isolated from human fluids. Such preparations are useful in therapeutic treatments of patients suffering from different diseases, for example herbes simplex.

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