Receptors: their identification, characterization, preparation a

Details Receptors: their identification, characterization, preparation a Receptors: their identification, characterization, preparation a

1988-11-30

1993-06-08

Saunders, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 6, 435 29, 4351723, 4352402, 436501, 935 36, 935 59, C12N 500, C12Q 102, C12Q 168, G01N 33566

Patent

active

052178676

ABSTRACT:
Disclosed are novel hormone and hormone-like receptors wherein the trans-activation transcription domain(s) is modified in terms of position and/or copy number or otherwise versus parent receptor, such novel receptors having increased trans-activation transcription activation properties surprisingly superior to the parent receptor. Also disclosed are the recombinant methods and means for preparing such receptors and assays based upon the use of such receptors for screening and identifying putative materials that can affect such receptors and/or for the expression via induced transcription of a reporter or other desired, preferably heterologous gene or DNA product.

REFERENCES:
patent: 4738922 (1988-04-01), Haseltine et al.
patent: 4859609 (1989-08-01), Dull et al.
patent: 4870009 (1989-09-01), Evans et al.
Giguere et al., Cell, 46, 645-652, 1986.
Gill et al., Cell., 51, 121-126, 1987.
The Merck Index, Tenth Edition, 1983, pp. 361-362.

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