Receptors for fibroblast growth factors

Details Receptors for fibroblast growth factors Receptors for fibroblast growth factors

1995-06-02

1998-01-13

Chan, Christina Y.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Hormone or other secreted growth regulatory factor,...

435 71, 435 7021, 436548, 530350, 5303879, 53038822, 5303891, 5303896, G01N 3353, C07K 100, C07K 1600, C12P 2108

Patent

active

057076324

ABSTRACT:
A fibroblast growth factor (FGF) receptor including a basic fibroblast growth factor receptor has been purified. Various forms have been identified including soluble forms lacking any transmembrane segment. DNA sequences encoding full-length fibroblast growth factor receptors and polypeptides comprising a portion of an FGF-R ligand-binding domain have been isolated and sequenced. These DNAs include DNAs encoding for a basic FGF-R and a human FGF-R and are operably linked to control sequences and expressed in a culture of a compatible host transformed, transfected or electrophoresed by a cloning vehicle containing the DNA sequence. The invention also comprises antibodies to the receptor, methods of synthesizing the growth factor receptor proteins, methods for providing analogs of the fibroblast growth factor receptors. Methods for evaluating compositions which promote or inhibit fibroblastic growth factors and compositions which are agonistic or antagonistic to fibroblast growth factor receptors are also provided. Diagnostic and therapeutic uses are described.

REFERENCES:
patent: 4394443 (1983-07-01), Weissman et al.
patent: 4668476 (1987-05-01), Bridgham et al.
patent: 4761371 (1988-08-01), Bell et al.
patent: 4785079 (1988-11-01), Gospodarowicz et al.
patent: 4859609 (1989-08-01), Dull et al.
patent: 4968607 (1990-11-01), Dower et al.
patent: 5229501 (1993-07-01), Keifer et al.
Lerner, Nature 299: 592-596, Oct. 1982.
Sevier et al., Clin. Chem. 27: 1797-1806, Nov. 1981.
Baird, et al., Proc. Nat'l. Acad. Sci. USA, vol. 85, pp. 2324-2328, 1988.
Burrus, et al., J. of Biol. Chem., vol. 264, pp. 18647-18653, 1989.
Clark-Lewis, et al., Science, vol. 231, pp. 134-139, 1986.
Feige, et al., J. of Biol. Chem., vol. 263 No. 28, pp. 14023-14029, 1988.
Gospodarowicz, et al., Endocrine Rev. vol. 8, pp. 95-114., 1987.
Hunkapiller, et al., Meth. Enzymol., vol. 91, pp. 399-413, 1983.
Imamura, et al., Biochem. Biophys. Res. Commun., vol. 155, pp. 583-590, 1988.
Isacchi, et al., Nuc. Acids Res., vol. 18, p. 2616, 1990.
Itoh, et al., Biochem. Biophys. Res. Comm., vol. 169, pp. 680-685, 1990.
Klein, Immunology: The Science of Self-Nonself Discrimination, John Wiley & Sons, New York, pp. 251-252 & 551-555, 1982.
Kornbluth, et al., Mol. Cell. Biol. vol. 8, pp. 5541-5544, 1988.
Lee, et al., Science, vol. 245, pp. 57-245, 1989.
Lee, et al., Nat'l. Mtg.--Am. Soc. Clin. Invest., vol. 37, p. 519A, 1989.
Lee, et al., J. Cell. Physiol.--Suppl. 13B, vol. 155, abstract #E513, 1989.
Mascarelli, et al., Biochem. Biophys. Res. Commun., vol. 146, pp. 478-486, 1987.
Neufeld, et al., J. Biol. Chem., vol. 261, pp. 5631-5637, 1986.
Neufeld, et al., J. Cell. Physiol., vol. 136, pp. 537-542, 1988.
Olwin, et al., J. Cell. Biol., vol. 103, p. 2979, 1986.
Pasquale, et al., Proc. Nat'l. Acad. Sci. USA, vol. 86 No. 14, pp. 5449-5453, 1989.
Pasquale, et al., Accession No. M24637. This nucleotide sequence was available through Gene Bank on or about Jun. 15, 1989.
Reid, et al., Proc. Nat'l. Acad. Sci. USA, vo. 87, pp. 1596-1600, 1990.
Risau, et al., EMBO J., vol. 7, pp. 959-962, 1988.
Ruta, et al., Oncogene, vol. 3, pp. 9-14, 1988.
Ruta, et al., Proc. Nat'l. Acad. Sci. USA, vol. 86, pp. 8722-8726, 1989.
Safran, et al., Oncogene, vol. 5, pp. 635-643, 1990.
Yarden, et al., Nature, vol. 323, pp. 226-232, 1986.

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