Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-09-18
2000-02-01
Ulm, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 12, 530350, 5303882, 435194, A61K 3817, C07K 1447, C07K 14705
Patent
active
060203064
ABSTRACT:
The present invention relates to an isolated receptor-type tyrosine kinase. The receptor-type tyrosine, in its naturally occurring form, is characterized by being reactive to monoclonal antibody III.A4, having an apparent molecular weight of approximately 120-150 kD in its glycosylated form, and having the N-terminal amino acid sequence E L I P Q P.
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MacPherson, B. in Radionuclides in Clinical Chemistry. Howard, et al (eds) 1980, chapter 6, pp. 77-90, Little, Brown and Company, USA, 1980.
Hirai, et al. (Dec. 1987) "A Novel Putative Tyrosine Kinase Receptor Encoded by the eph Gene" Science 238:1717-1720.
Lhotak, et al. (May 1991) "Characterization of Elk, A Brain-Specific Receptor Tyrosine Kinase" Molecular and Cellular Biology 11:2496-2502.
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Pasquale (Jul. 1991) "Identification of Chicken Embryo Kinase 5, A Developmentally Regulated Receptor-Type Tyrosine Kinase of the Eph Family" Cell Regulation 2:523-534.
Sajjadi, et al. (Aug. 1991) "identified of a New eph-Related Receptor Tyrosine Kinase Gene from Mouse and Chicken that is Developmentally Regulated and Encodes at Least Two Forms of the Receptor" The New Biologist 3(8) :769-778.
Flanagan, et al. (Oct. 5, 1990) "The Kit Ligand: A Cell Surface Molecule Altered in Steel Mutant Fibroblasts" Cell 63:185-194.
Reeck, et al. (Aug. 28, 1987) "`Homology` in Proteins and Nucleic Acids: A Terminology Muddle and a Way Out of it" Cell 50:667.
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Boyd Andrew W.
Simpson Richard
Ward Larry David
Wicks Ian
Wilkinson David
Amrad Corporation Limited
Saoud Christine
Ulm John
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