Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-09-19
2006-09-19
Prouty, Rebecca (Department: 1652)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007100, C435S007800, C435S021000, C435S196000, C536S023200
Reexamination Certificate
active
07108994
ABSTRACT:
A novel receptor-type protein tyrosine phosphatase (RPTP) protein or glycoprotein and the DNA coding therefor is expressed in a wide variety of mammalian tissues. Included in this family of proteins are human RPTPα, human RPTPβ and human RPTPγ. The RPTP protein or glycoprotein may be produced by recombinant means. Antibodies to the proteins, methods for measuring the quantity of the proteins, methods for screening compounds, such as drugs, which can bind to the proteins and inhibit or stimulate their activity, are provided.
REFERENCES:
patent: WO 92/01050 (1992-01-01), None
patent: WO 94/01119 (1994-01-01), None
patent: WO 94/03610 (1994-02-01), None
patent: WO 94/09037 (1994-04-01), None
Berger et al., “Guide to Molecular Cloning Techniques,”Meth. Enzymol. 152:393-399, 415-423, 432-447, 663-704 (1987).
Butler et al., “Characterization of a membrane-associated phosphotyrosyl protein phosphatase from the A431 human epidermoid carcinoma cell line,”Eur. J. Biochem, 185:475-483 (1989).
Cannoll et al., “The Expression of a novel receptor-type tyrosine phosphatase suggests a role in morphogenesis and plasticity of the nervous system,”Development Brain Research, Oct. 15, 1993, pp. 293-298, vol. 75, No. 2.
Carney et al., “Monoclonal antibody specific for an activated RAS protein,”Proc. Nat. Acad. Sci. USA, Oct. 1986, pp. 7485-7489, vol. 83.
Charbonneau et al., “Human placenta protein-tyrosine-phosphatase: Amino acid sequence and relationship to a family of receptor-like proteins,”Proc. Natl. Acad. Sci. USA86:5252-5256 (1989).
Charbonneau et al., “The leukocyte common antigen (CD45): A putative receptor-linked protein tyrosine phosphatase,”Proc. Natl. Acad. Sci. USA85:7182-7186 (1988).
Chernoff et al., “Cloning of a cDNA for a major human protein-tyrosine-phosphatase,”Proc. Natl. Acad. Sci. USA, 87:2735-2739 (1990).
Church, et al., “Genomic Sequencing”,Proc. Natl. Acad. Sci., vol. 81, pp. 1994-1995, (1984).
Cool et al., “cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family,”Proc. Natl. Acad. Sci. USA86:5257-5261 (1989).
Cool et al., “Overexpression of a T-cell protein tyrosine phosphatase (PTPase) in BHK Cells,”FASEB J. 4:A2078 (abstr. 2230) (1990).
Cyert and Thorner, “Putting it on and taking if off: Phosphoprotein phosphatase involvement in cell cycle regulation,”Cell57:891-893 (1989).
Daum et al., “Characterization of a human recombinant receptor-linked protein tyrosine phosphatase,”J. Biol. Chem., 266:12211-12215 (1991).
Fischer et al., “Protein tyrosine phosphatases: A diverse family of intracellular and transmembrane enzymes,”Science253:401-406 (1991).
Gebbink et al., “Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase,”FEBS Lett. 290:123-130 (1991).
George and Parker, “Preliminary characterization of phosphotyrosine phosphatase activities in human peripheral blood lymphocytes: Identification of CD45 as a phosphotyrosine phosphatase,”J. Cell Biochem. 42:71-81 (1990).
Gu et al., “Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1,”Proc. Natl. Acad. Sci. USA88:5867-5871 (1991).
Guan et al., “Protein Tyrosine Phosphatase Activity of an Essential Virulence Determinant in Yersinia,” Science, Aug. 3, 1990, pp. 553-556, vol. 249.
Guan et al., “Cloning and expression of a protein-tyrosine-phosphatase,”Proc. Natl. Acad. Sci. USA87:1501-1505 (1990).
Hall et al., “Complete exon-intron organization of the human leukocyte common antigen (CD45) gene,”J. Immunol. 141:2781-2787 (1988).
Hariharan et al., “Cloning and characterization of a receptor-class phosphotyrosine phosphatase gene expressed on central nervous system axons in Drosophila melanogaster,”Proc. Natl. Acad. Sci. USA88:11266-11270 (1991).
Hunter, “Protein-tyrosine phosphatases: The other side of the coin,”Cell58:1013-1016 (1989).
Jirik et al., “Cloning and chromosomal assignment of a widely expressed human receptor-like protein-tyrosine phosphatase,”FEBS Lett. 273:239-242 (1990).
Jirik et al., “Cloning of a novel receptor-linked protein tyrosine phosphatase from a human hepatoblastoma cell line,”FASEB J. 4A:2082 (Abstr. 2253) (1990).
Jones et al., “Phosphotyrosyl-protein phosphatases,”J. Biol. Chem. 264:7747-7753 (1989).
Kaplan et al., “Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain,”Proc. Natl. Acad. Sci. USA87:7000-7004 (1990).
Kiener and Mittler, “CD45-protein tyrosine phosphatase cross-linking inhibits T-cell receptor CD3-mediated activation in human T-cells,”J. Immunol. 143:23-28 (1989).
Klarlund, “Transformation of cells by an inhibitor of phosphatases acting on phosphotyrosine in proteins,”Cell41:707-717 (1985).
Krueger and Saito, “A human transmembrane protein-tyrosine-phosphatase, PTP, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases,”Proc. Natl. Acad. Sci. USA, 1992, pp. 7417-7421, vol. 89, No. 16.
Krueger et al., “Structural diversity and evolution of human receptor-like protein tyrosine phosphatases,”EMBO J. 9:3241-3252 (1990).
Levy et al., “The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system,”Journal of Biological Chemistry, May 15, 1993, pp. 10573-10581, vol. 268, No. 14.
Lombroso et al., “Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum,”Proc. Natl. Acad. Sci. USA 88:7242-7246 (1991).
Matthews et al., “Characterization of hemotopoletic intracellular protein tyrosine phosphatases: Description of a phosphatase containing an SH2 Domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences,”Molec. and Cell. Biol. 12:2396-2405 (1992).
Matthews et al., “Identification of an additional member of the protein-tyrosine-phosphatase family: Evidence for alternative splicing in the tryosine phosphatase domain,”Proc. Natl. Acad. Sci. USA87:4444-4448 (1990).
Mustelin et al., “Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase,”Proc. Natl. Acad. Sci. USA86:6302-6306 (1989).
Ohagi et al., “Sequence of a cDNA encoding human LRP (leukocyte common antigen-related peptide),”Nucl. Acids Res. 18:7159 (1990).
Ostergaard et al., “Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines,”Proc. Natl. Acad. Sci. USA86:8959-8963 (1989).
Pallen et al., “Purification of a phosphotyrosine phosphatase that dephosphorylates the epidermal growth factor receptor autophosphorylation sites,”Ann. N.Y. Acad. Sci. 551:299-308 (1988).
Pingel and Thomas, “Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation,”Cell58:1055-1065 (1989).
Plutzky et al., “Isolation of a src homology 2-containing tyrosine phosphatase,”Proc. Natl. Acad. Sci. USA89:1123-1127 (1992).
Pot and Dixon, “A thousand and two protein tyrosine phosphatases,”Biochem. Biophys. Acta. 1136:35-43 (1992).
Ralph et al., “Structural variants of human T200 glycoprotein (leukocyte-common antigen),”EMBO J. 6:1251-1257 (1987).
Saiki et al., “Enzymatic amplification of .beta.-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia,” SCIENCE, Dec. 20, 1985, pp. 1350-1354, vol. 230.
Sap et al., “Cloning and expression of a widely expressed receptor tyrosine phosphat
Sap Jan M.
Schlessinger Joseph
Klauber & Jackson LLC
New York University
Prouty Rebecca
LandOfFree
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