Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1991-06-21
1996-11-26
Wax, Robert A.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4353201, 530350, C12N 516, C12N 1585, C07K 14705
Patent
active
055784836
ABSTRACT:
Disclosed is an analysis of domains of receptors of the steroid/thyroid hormone superfamily, and particularly of the glucocorticoid receptor, to identify requirements for the trans-acting transcriptional repression activities of the receptors. Based on the analysis, certain novel receptor analogs are provided, as are various novel DNAs, expression vectors, cells and transgenic animals as well as novel methods of using trans-acting transcription-repressing analogs of the receptors in various applications. These applications include gene therapy, screening of cells in culture or transgenic animals for compositions effective to treat various diseases due to inability to properly respond to hormones of the steroid or thyroid hormone group, and screening of cells in culture for ligands that are capable, upon binding to one of the receptors, to activate its trans-acting transcription activating and trans-acting transcription-repressing activities.
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Evans Ronald M.
Hollenberg Stanley M.
Oro Anthony E.
Carlson K. Cochrane
Ramos Robert T.
Reiter Stephen E.
The Salk Institute for Biological Studies
Wax Robert A.
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