Receptor that binds trail

Details Receptor that binds trail Receptor that binds trail

1997-06-26

2000-06-06

Kemmerer, Elizabeth

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 243, 435 6, 4353201, 435325, 4352523, 435 691, 530350, C07H 2104, C12N 1512, C12N 1563

Patent

active

060720476

ABSTRACT:
A protein designated TRAIL receptor binds the protein known as TNF-Related Apoptosis-Inducing Ligand (TRAIL). The TRAIL receptor finds use in purifying TRAIL or inhibiting activities thereof. Isolated DNA sequences encoding TRAIL-R polypeptides are provided, along with expression vectors containing the DNA sequences, and host cells transformed with such recombinant expression vectors. Antibodies that are immunoreactive with TRAIL-R are also provided.

REFERENCES:
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Cross et al, Purification of CpG islands using a methylated DNA binding col., Nature Genetics, vol. 6, pp. 236-244, 1994.
Berger et al, Guide to Molecular Cloning Techniques, Methods in Enzymology, vol. 152, Academic Press, Inc., pp. 661-673, 1987.
George et al., Current Methods in Sequence Comparison and Analysis, selected methods and applications. Edited by David H. Schlesinger, Alan R. Liss, Inc., New York, pp. 124-129, 1988.
White A. et al., Principles of Biochemistry, vol. 6, McGraw-Hill, Inc., pp. 155-158, 1978.
Bowie et al., Deciphering the message in Protein sequences: Tolerance to Amino Acid Substitutions. Science, vol. 247, pp. 1306-1310, 1990.
Embl-est Database Accession No. AA223122, zr06g05.rl Stratagene NT2 neuronal precursor 937230 Homo Sapian cDNA clone 650744 5' sequence. Submitted by Hillier et al, Feb. 19, 1998.

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