Receptor specific transepithelial transport of therapeutics

Details Receptor specific transepithelial transport of therapeutics Receptor specific transepithelial transport of therapeutics

1997-07-24

2000-02-29

Cunningham, Thomas M.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Structurally-modified antibody, immunoglobulin, or fragment...

4241781, 5303871, 53038822, A61K 39385, A61K 3944

Patent

active

060306130

ABSTRACT:
The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.

REFERENCES:
patent: 4261973 (1981-04-01), Lee et al.
patent: 4650675 (1987-03-01), Borel et al.
patent: 4902495 (1990-02-01), Kaliner et al.
patent: 5116964 (1992-05-01), Capon et al.
patent: 5169627 (1992-12-01), Cunningham-Rundles
patent: 5277894 (1994-01-01), Strauss et al.
patent: 5349053 (1994-09-01), Landolfi
patent: 5428130 (1995-06-01), Capon et al.
patent: 5455165 (1995-10-01), Capon et al.
patent: 5514582 (1996-05-01), Capon et al.
patent: 5534496 (1996-07-01), Lee et al.
patent: 5541087 (1996-07-01), Lo et al.
patent: 5565335 (1996-10-01), Capon et al.
patent: 5658762 (1997-08-01), Zanetti et al.
patent: 5698679 (1997-12-01), Nemazee
patent: 5726044 (1998-03-01), Lo et al.
Zaghouani, H. et al., Science 259:224-227, Presentation of a viral T cell epitope expressed in the CDR3 region of a self immunoglobulin molecule, Jan. 1993.
Squire, C.M. et al., Journal of Immunology, 4388-4396.
Gosselin, E.J. et al., 149:3477-3481 (1992).
Abstract Usui, Junko et al., Hoechst Japan Ltd., Japan.
Berryman et al., J. Histochem. Cytochem. 38(2):159-170 (1980).
Service, Science 265:1522-1524 (1994).
Patel et al., FEBS Lett. 234(2):321-325 (1988).
Fritsche et al., J. Allergy Clin. Immunol. 93:778-786 (1994).
Story et al., J. Exp. Med., 180:2377-2381 (1994).
Kobayashi et al., J. Immunol. 146:68-74 (1991).
Rabinovich et al., Science 265:1401-1404 (1994).
Simister et al., Nature 337:184-187 (1989).
Czerkinsky et al., Infect. Immun. 57:1072-1077 (1989).
Elson et al., J. Immunol. 132:2736-2741 (1984).
Langermann et al., Nature 372:552-555 (1994).
Simister, American Society of Microbiology Press, Washington, DC pp. 57-73 (1990).
Burmeister et al., Nature 372:379-383 (1994).
Canfield et al., J. Exp. Med. 173:1483-1491 (1991).
Woof et al., Mol. Immunol. 23:319-330 (1986).
Lund et al., J. Immunol. 147:2657-2662 (1991).
Huber et al., Mol. Biol. 230:1077-1083 (1993).
Guyer et al., J. Immunol. 117:587-593 (1976).
Ahouse et al., J. Immunol. 151:6076-6088 (1993).
Dertzbaugh et al., CRC Press:119-131 (1990).
Elson et al., J. Immunol. 133:2892-2897 (1984).
Elson et al., J. Immunol. 135:930-932 (1985).
Lencer et al., J. Clin. Invest. 92:2941-2951 (1993).
Lencer et al., J. Cell Biol. 117:1197-1209 (1992).
Mostov et al., Cell 43:389-390 (1985).
Langermann et al., J. Exp. Med. 180:2277-2286 (1994).
Fridman, W.H. FASEB, J.,5(12):2684-2690 (Sep. 1991).
Israel et al., J. of Immunol. 154(12):6246-6251 (Jun. 15, 1995).
Service, R.F., Science 265:1522-1524 (Sep. 9, 1994).
Halina Borel et al., Journ. of Immunol. Methods: 159-168 (Sep. 20, 1990).
Roseli Farges al.-Fed. of European Bioche Biochem Soc. vol. 335 (3):305-308 (Oct. 12, 1993).
Nagy Mikael, et al., Lupus, vol. 3(173-179 (1994).
Malini Raghavan et al., Immunity, vol. 1:303-315 (Jul. 1994).
Victor Ghetie et al., Immunology Today, vol. 18 (12):592 (Dec. 1997).
International Search Report--PCT/US98/15395 (B0801/7117WO).
Supplementary Search Report--EP 96 90 3522.
Paul, W.F. (ed) Fundamental Immunology, 4th edition, pp. 1399-1401 (1999).

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