Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-05-25
1997-09-09
Tsang, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530324, C07K 1458, A61K 3800
Patent
active
056657048
ABSTRACT:
Human receptor selective atrial natriuretic factor variants containing various substitutions, especially G16R, show equal potency and binding affinity for the human A-receptor but have decreased affinity for the human clearance or C-receptor. These ANF variants have natriuretic, diuretic and vasorelaxant activity but have increased metabolic stability, making them suitable for treating congestive heart failure, acute kidney failure and renal hypertension.
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Burnier John
Cunningham Brian C.
Lowe David
McDowell Robert S.
Oare David
Genentech Inc.
Gupta Anish
Kubinec Jeffrey S.
Tsang Cecilia
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