Receptor recognition factors, protein sequences and methods of u

Details Receptor recognition factors, protein sequences and methods of u Receptor recognition factors, protein sequences and methods of u

1997-10-10

2000-09-26

Spector, Lorraine

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4323201, 935 9, 536 235, C12P 2106, C07H 2104

Patent

active

061241180

ABSTRACT:
Receptor recognition factors exist that recognizes the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted with interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFN.alpha. and IFN.gamma.. Specific DNA and amino acid sequences for various human and murine receptor recognition factors are provided, as are polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested. The polypeptides confirm direct involvement of tyrosine kinase in intracellular message transmission. Numerous diagnostic and therapeutic materials and utilities are also disclosed.

REFERENCES:
patent: 5534409 (1996-07-01), Groner et al.
D. Mazel et al., "Highly Repetitve DNA Sequences in Cyanobacterial Genomes", J. Bacteriology 172(5):2755-2761, May 1990.
Improta et al., 1994, Proc. Natl. Acad. Sci. USA 91:4776-80.
Shuai et al., 1994, Cell 76:821-28.
Eck et al., 1993, Nature 362:87-91.
Felder et al., 1993, Mol. Cell. Biol. 13:1449-55.
Khan et al., 1993, Proc. Natl. Acad. Sci. USA 90:6806-10.
Muller et al., 1993, EMBO J. 12:422-28.
Muller et al., 1993, Nature 366:129-35.
Pearse et al., 1993, Proc. Natl. Acad. Sci. 90:4314-18.
Sadowski et al., 1993, Science 261:1739-44.
Shuai et al., 1993, Nature 366:580-83.
Shuai et al., 1993, Science 261:1744-46.
Songyang et al., 1993, Cell 72:767-78.
Watling et al., 1993, Nature 366:166-70.
Booker et al., 1992, Nature 358:684-87.
Fu, 1992, Cell 70:323-35.
Fu et al., 1992, Proc Natl. Acad Sci. USA 89:7840-43.
Overduin et al., 1992, Cell 70:697-704.
Schindler et al., 1992, Proc. Natl. Acad. Sci. USA 89:7836-39.
Schildler et al., 1992, Science 257:809-13.
Shuai et al., 1992, Science 258:1808-12.
Velazqez et al., 1992, Cell 70:313-22.
Decker et al., 1991, Mol. Cell. Biol. 11:5147-53.
Decker et al., 1991, EMBO J. 10:927-32.
Kaplan et al., 1991, Nature 350:158-60.
Kessler and Levy, 1991, J. Biol. Chem. 266:23471-76.
Koch et al., 1991, Science 252:668-74.
Lew et al., 1991, Mol. Cell. Biol. 11:182-91.
McKendry et al, 1991, Proc. Natl. Acad. Sci. USA 88:11455-59.
Qureshi et al., 1991, J. Biol. Chem. 266:20594-97.
Fu et al., 1990, Proc. Natl. Acad. Sci. USA 87:8555-59.
Kessler et al., 1990, Genes Dev. 4:1753-65.
Lee et al., 1990, Mol. Cell. Biol. 10: 1982-88.
Levy and Darnell, 1990, The New Biologist 2:923-28.
Reich and Pfeffer, 1990, Proc. Natl. Acad. Sci. USA 87:876-65.
Uze et al., 1990, Cell 60:225-34.
Dale et al., 1989, Proc. Natl. Acad. Sci. USA 86:1203-7.
Decker et al., 1989, EMBO J. 8:2009-14.
Levy et al., 1989, Genes Dev. 3:1362-71.
Lew et al., 1989, Mol. cell Biol. 9:5404-11.
Aguet et al., 1988, Cell 55:273-80.
Levy et al., 1988, Genes Dev. 2:383-93.
Rudd et al., 1988, Proc. Natl. Acad. Sci. USA 85:5190-94.
Veillette et al., 1988, Cell 55:301-8.
Celis et al., 1987, Leukemia 1:800-13.
Leung et al., 1987, Nature 330:537-43.
Chodosh et al., 1986, Mol. Cell. Biol. 6:4723-33.
Friedman et al., 1984, Cell 38:745-55.

Affiliated with

Also associated with

Rating

Receptor recognition factors, protein sequences and methods of u does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Receptor recognition factors, protein sequences and methods of u, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Receptor recognition factors, protein sequences and methods of u will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2098999