Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1991-06-19
1993-06-01
Chan, Y. Christina
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
514 8, 53038822, 5303891, C07K 1500, A61K 3743, A61K 3900, A61K 3510
Patent
active
052161269
ABSTRACT:
An isolated TGF-.beta. supergene family (TSF) receptor polypeptide is provided. This polypeptide preferably is an inhibin/activin receptor polypeptide and has at least 75% sequence identity with the mature human inhibin/activin receptor sequence. Also provided is a method for purifying TGF-.beta. supergene family members such as inhibin or activin using the polypeptide, and a method for screening for compounds with TGF-.beta. supergene family member activity by contacting the compound with the polypeptide and detecting if binding has occurred and the compound is active.
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Cox Edward T.
Mather Jennie P.
Sliwkowski Mary B.
Woodruff Teresa K.
Adams Donald E.
Chan Y. Christina
Genentech Inc.
Hasak Janet E.
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