Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1993-11-03
1998-10-13
Kemmerer, Elizabeth C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530300, 530324, 530325, 530326, 530327, 530328, 530329, 530330, C07K 14705, C07K 1400, C07K 700
Patent
active
058213325
ABSTRACT:
The invention provides purified ACT-4 receptor polypeptides, antibodies against these polypeptides and nucleic acids encoding ACT-4 receptor polypeptides. Also provided are methods of diagnosis and treatment using the same. ACT-4 receptors are preferentially expressed on the surface of activated CD4.sup.+ T-cells. ACT-4 receptors are usually expressed at low levels on the surface of activated CD8.sup.+ cells, and are usually substantially absent on resting T-cells, and on monocytes and B-cells (resting or activated). An exemplary ACT-4 receptor, termed ACT-4-h-1, has a signal sequence, an extracellular domain comprising three disulfide-bonded intrachain loops, a transmembrane domain, and an intracellular domain.
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Buck David
Engleman Edgar G.
Godfrey Wayne
Dreger Walter H.
Kemmerer Elizabeth C.
Kresnak Mark T.
The Board of Trustees of the Leland Stanford Junior University
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